X-ray crystallography

X-ray crystallography is a technique that uses X-ray diffraction patterns to determine high-resolution, three-dimensional structures of molecules such as proteins, small organic molecules, and materials. The substance of interest must be in crystalline form, which typically requires testing various crystallization conditions.

Latest Research and Reviews

News and Comment

  • News & Views |

    Prokaryotic genomes are rife with highly similar toxin–antitoxin modules that need to be protected and diversified at the same time. Studies of paralogous modules now reveal how evolution secures insulation between related systems, without compromising toxin inhibition.

    • Anastasia Liuzzi
    •  & Ditlev E. Brodersen
    Nature Chemical Biology 17, 1216-1217
  • News & Views |

    Targeting cholecystokinin receptors (CCKRs) signaling has become an attractive therapeutic strategy for many diseases. The description of cryo-EM structures of CCKRs in the active or inactive states reveal the molecular mechanism of ligand recognition and G-protein-coupling promiscuity.

    • Lin Cheng
    •  & Zhenhua Shao
    Nature Chemical Biology 17, 1213-1214
  • News & Views |

    Graspetides are an important class of ribosomal natural products with potent bioactivities. New structural information provides insights into substrate recognition and catalysis, including a rare glimpse into the interactions between a tailoring enzyme and the core of the precursor peptide.

    • Jesko Koehnke
    Nature Chemical Biology 17, 1118-1119
  • News & Views |

    The structure of a giant ubiquitin E3 ligase sheds light on its activation in a substrate-dependent manner and shows how a single E3 enzyme uses distinct recognition modules to confer substrate specificity.

    • Hidde Ploegh
    Nature Chemical Biology 17, 1014-1015