Translation

Translation is the process by which a protein is synthesized by the ribosome, using a messenger RNA (mRNA) template.

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  • News & Views |

    Cytosolic DNA sensing by the cGAS–STING pathway is critical for sustaining an innate immune defense program. A new study shows that the cGAS–STING pathway signals by a non-canonical mechanism to control protein translation through the unfolded protein response sensor PERK, and thereby contributes to cellular senescence and organ fibrosis.

    • Younis Hazari
    •  & Claudio Hetz
    Nature Cell Biology 24, 602-604
  • News & Views |

    Increased tRNA abundance and amino acid coupling generally promote increased oncogenesis. By contrast, a new study shows that in breast cancer, the leucyl-tRNA synthetase LARS suppresses transformation and tumour development by increasing tRNA-LeuCAG translation of certain tumour suppressor mRNAs.

    • C. Theresa Vincent
    •  & Robert J. Schneider
    Nature Cell Biology 24, 287-289
  • Research Highlights |

    Thandapani et al. examined the role for tRNA biogenesis in T cell acute lymphoblastic leukaemia (T-ALL), and found that T-ALL cells are sensitive to valine tRNA levels, which could be exploited therapeutically by dietary valine restriction.

    • Sarah Seton-Rogers
  • News & Views |

    Genetic code expansion is emerging as a promising strategy to precisely regulate protein expression. A new study engineered cells that enabled noncanonical-amino-acid-triggered insulin expression to rapidly regulate blood glucose levels in a diabetic mouse model.

    • Jicheng Yu
    • , Yuqi Zhang
    •  & Zhen Gu