Totipotent stem cells

  • Letter |

    Cultures of expanded potential stem cells can be established from individual eight-cell blastomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells, highlighting the feasibility of establishing expanded potential stem cells for other mammalian species.

    • Jian Yang
    • , David J. Ryan
    •  & Pentao Liu
  • Review Article |

    In response to the need for a defined set of criteria to assess stem-cell potency, this review proposes guidelines for the evaluation of newly derived pluripotent stem cells, from functional assays to integrative molecular analyses of transcriptional, epigenetic and metabolic states.

    • Alejandro De Los Angeles
    • , Francesco Ferrari
    •  & George Q. Daley