Nature

Synthetic organisms

Synthetic organisms are organisms for which a substantial portion of the genome or the entire genome has been designed or engineered.

Latest Research and Reviews

Research
01 December 2021 | Open Access

Genome-wide unbalanced expression bias and expression level dominance toward Brassica oleracea in artificially synthesized intergeneric hybrids of Raphanobrassica
- Libin Zhang
- , Jianjie He
- & Maoteng Li
Horticulture Research 8, 246
Research | 19 February 2020

Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

Single-cell RNA sequencing and spatial transcriptomics reveal that the somitogenesis clock is active in mouse gastruloids, which can be induced to generate somites with the correct rostral–caudal patterning.
- Susanne C. van den Brink
- , Anna Alemany
- & Alexander van Oudenaarden
Nature 582, 405-409
Reviews | 05 February 2018

Engineering bacteria for diagnostic and therapeutic applications

Advances in synthetic biology allow the generation of ever more sophisticated engineered bacteria. In this Review, Riglar and Silver showcase recent highlights in engineered bacterial therapeutics and diagnostics and discuss how best to develop them for clinical application.
- David T. Riglar
- & Pamela A. Silver
Nature Reviews Microbiology 16, 214-225
Research | 31 August 2015

Programmed synthesis of three-dimensional tissues

DNA-programmed assembly of cells (DPAC) allows the reconstitution of organoid-like structures with controlled size, shape, cell-type composition and spatial heterogeneity.
- Michael E Todhunter
- , Noel Y Jee
- & Zev J Gartner
Nature Methods 12, 975-981

All Research & Reviews

News and Comment

Research Highlights | 21 August 2019

Differentiating bacteria

Two studies report synthetic genetic circuits for inducible asymmetric cell division that give rise to cellular differentiation in Escherichia coli.
- Ashley York
Nature Reviews Microbiology 17, 588-589
Comments & Opinion | 13 April 2018

The challenges facing synthetic biology in eukaryotes

Synthetic biology is maturing into a true engineering discipline for model microorganisms, but remains far from straightforward for most eukaryotes. Here, we outline the key challenges facing those trying to engineer biology across eukaryota and suggest areas of focus that will aid future progress.
- Francesca Ceroni
- & Tom Ellis
Nature Reviews Molecular Cell Biology 19, 481-482
Research Highlights | 28 April 2016

A minimal bacterial cell

Nature Methods 13, 396

All News & Comment

Advanced search

Quick links