Chemical synthesis

Chemical synthesis is the process by which one or more chemical reactions are performed with the aim of converting a reactant or starting material into a product or multiple products. Chemical synthesis is at the heart of much chemistry research as it is the basis for discovering compounds with new physical or biological properties.


Latest Research and Reviews

News and Comment

  • News & Views |

    Methods for the synthesis of bicyclo[1.1.1]pentanes (BCPs) typically rely on the release of strain energy, but these routes cannot easily introduce substituents on the BCP bridges. Now, an intramolecular coupling gives access to multi-substituted BCPs, through the synthesis of bridge-substituted bicycloalkyl boronic esters.

    • Cara E. Brocklehurst
    •  & Edward A. Anderson
    Nature Chemistry 13, 928-930
  • News & Views |

    Benzene rings are almost unbreakable in typical reaction conditions. Chemistry has now been developed that selectively breaks these rings open, highlighting their potential as building blocks for making open-chain molecules.

    • Mark R. Crimmin
    Nature 597, 33-34
  • News & Views |

    Although the natural lasso peptide microcin J25 remains an elusive target for total chemical synthesis itself, this topologically non-trivial building block has now been used to construct a range of interlocked molecular architectures including rotaxanes, catenanes and daisy chains.

    • Jan H. van Maarseveen
    Nature Chemistry 13, 822-823
  • News & Views |

    Carbon–carbon single bonds are generally among the least reactive chemical bonds. While olefin metathesis reactions are well established, direct metathesis of C–C single bonds is rare. Now, a C–C single bond metathesis reaction has been developed, forming cross-biaryl products from unstrained homo-biaryl compounds.

    • Michael M. Gilbert
    •  & Daniel J. Weix
    Nature Chemistry 13, 818-820
  • Research Highlights |

    The supramolecular assembly of oligomers encoded with complementary recognition units enables duplex hybridization with helical structure.

    • Colette Whitfield