Chemical synthesis

Chemical synthesis is the process by which one or more chemical reactions are performed with the aim of converting a reactant or starting material into a product or multiple products. Chemical synthesis is at the heart of much chemistry research as it is the basis for discovering compounds with new physical or biological properties.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    A silicon-linker that tethers a diyne and a diynophile provides new mechanistic insight and control of hexadehydro-Diels–Alder (HDDA) reactions.

    • Colette Whitfield
  • News & Views |

    Diazoolefins are long-sought-after compounds, but experimental evidence for them is limited because of their high reactivity. Now, it has been shown that the reaction of N-heterocyclic olefins with nitrous oxide provides access to diazoolefins, enabling structural characterization and applications in organometallic and synthetic chemistry.

    • Claire Empel
    •  & Rene M. Koenigs
    Nature Chemistry 13, 1030-1032
  • News & Views |

    Aziridines — three-membered nitrogen-containing heterocycles — are important synthetic targets, but N-alkyl aziridines are difficult to synthesize. Now, an electrochemical method, involving a dicationic intermediate, enables the coupling of alkenes and amines.

    • Tiffany Piou
    •  & Louis-Charles Campeau
    Nature Chemistry 13, 1027-1028
  • Research Highlights |

    An article in Nature Chemistry reports a tip-manipulated approach to build custom nanoarchitectures on a surface by activating, orienting and coupling together individual building blocks.

    • Ariane Vartanian
  • News & Views |

    Methods for the synthesis of bicyclo[1.1.1]pentanes (BCPs) typically rely on the release of strain energy, but these routes cannot easily introduce substituents on the BCP bridges. Now, an intramolecular coupling gives access to multi-substituted BCPs, through the synthesis of bridge-substituted bicycloalkyl boronic esters.

    • Cara E. Brocklehurst
    •  & Edward A. Anderson
    Nature Chemistry 13, 928-930
  • News & Views |

    Benzene rings are almost unbreakable in typical reaction conditions. Chemistry has now been developed that selectively breaks these rings open, highlighting their potential as building blocks for making open-chain molecules.

    • Mark R. Crimmin
    Nature 597, 33-34