Supramolecular assembly

Supramolecular assembly is the formation of a well-defined complex of molecules held together by noncovalent bonds. It is usually used to describe large groups of molecules that form sphere-, rod- or sheet-like species.

Latest Research and Reviews

News and Comment

  • News & Views |

    Cryo-EM analysis reveals the mechanism by which chromatin is compacted at the centromere by the H3 histone variant CENP-N. Intriguingly, despite the structural differences between CENP-N and linker H1 histones, both appear to similarly compact higher-order nucleosome structures.

    • Katrina V. Good
    •  & Juan Ausió
  • News & Views |

    Light-activated protein actuators composed of bioengineered motors and molecular scaffolds achieve millimetre-scale mechanical work, which holds promise for microrobotics applications.

    • Henry Hess
    Nature Materials 20, 1040-1041
  • News & Views |

    A new cryo-EM structure of the bacterial flagellar hook, which connects the motor to the flagellar filament, reveals 11 distinctive conformations of the subunit. The cooperative dynamic switching among these states offers a dramatic extension of two-state models of protein allostery.

    • Edward H. Egelman
  • News & Views |

    All current evidence indicates a central role for α-synuclein (α-SYN) amyloid fibrils in Parkinson's disease and other synucleinopathies, but the precise relationship between amyloid aggregates and the resulting phenotype remains poorly understood, partly because of the lack of reliable three-dimensional structures. In this issue, the structure of a toxic α-SYN fibril is now presented at unprecedented resolution.

    • Wouter Peelaerts
    •  & Veerle Baekelandt