Structure elucidation

Structure elucidation is the process of determining the chemical structure of a compound. For organic compounds, it will often involve the use of nuclear magnetic resonance spectroscopy (NMR spectroscopy). Other characterization techniques include mass spectrometry, infrared spectroscopy and X-ray crystallography.

Latest Research and Reviews

News and Comment

  • News & Views |

    Diazoolefins are long-sought-after compounds, but experimental evidence for them is limited because of their high reactivity. Now, it has been shown that the reaction of N-heterocyclic olefins with nitrous oxide provides access to diazoolefins, enabling structural characterization and applications in organometallic and synthetic chemistry.

    • Claire Empel
    •  & Rene M. Koenigs
    Nature Chemistry 13, 1030-1032
  • News & Views |

    Thirty years ago the assembly of molecular ‘tectons’ into organic networks with large chambers using directional non-covalent interactions — hydrogen bonds — provided a blueprint for the synthesis of porous functional materials through crystal engineering.

    • Andrew I. Cooper
    Nature Chemistry 13, 620-621
  • Comments & Opinion
    | Open Access

    Polymorphs, crystals with different structure and properties but the same molecular composition, arise from the subtle interplay between thermodynamics and kinetics during crystallisation. In this opinion piece, the authors review the latest developments in the field of polymorphism and discuss standing open questions.

    • Aurora J. Cruz-Cabeza
    • , Neil Feeder
    •  & Roger J. Davey
  • News & Views |

    Most compounds form crystals so small that scientists cannot experimentally determine their atomic structures using X-ray crystallography. Microcrystal electron diffraction now provides a unique solution for this challenge.

    • Oleg Sitsel
    •  & Stefan Raunser
    Nature Chemistry 11, 106-108