Stroke

Blood vascular leakage in conjunction with stroke causes edema and a worsened outcome. Through augmented and selective tyrosine phosphatase activity, endothelial junctions can be sealed, resulting in reduced stroke volume and improved survival.

A recent paper published in Science Translational Medicine presents evidence for a role of the enzyme autotaxin in excitotoxicity after stroke.

Patients with CYP2C19 mutations may have suboptimal responses to clopidogrel, but another anti-platelet agent — ticagrelor — may help to prevent stroke recurrence.