Stem-cell niche

  • Article |

    Stress inhibits  hair growth in mice through the release of the stress hormone corticosterone from the adrenal glands, which inhibits the activation of hair follicle stem cells by suppressing the expression of a secreted factor, GAS6, from the dermal niche.

    • Sekyu Choi
    • , Bing Zhang
    •  & Ya-Chieh Hsu
  • Article |

    A combination of fluorescent antibodies is used to build visual maps of all myeloid cells in the bone marrow, providing new insight into how the bone marrow microenvironment regulates cell-fate decisions.

    • Jizhou Zhang
    • , Qingqing Wu
    •  & Daniel Lucas
  • Letter |

    Hypoxia in the shoot meristem of Arabidopsis links the regulation of metabolic activity to development by inhibiting proteolysis of a substrate of the N-degron pathway, which controls class-III homeodomain-leucine zipper transcription factors.

    • Daan A. Weits
    • , Alicja B. Kunkowska
    •  & Francesco Licausi
  • Letter |

    In zebrafish embryogenesis, nascent haematopoietic stem and progenitor cells (HSPCs), homing to a vascular niche for retention, are ushered by patrolling and guiding macrophages through integrin-mediated cell-cell recognition.

    • Dantong Li
    • , Wenzhi Xue
    •  & Weijun Pan
  • Letter |

    Trophoblast and embryonic stem cells interact in vitro to form structures that resemble early blastocysts, and the embryo provides signals that drive early trophectoderm development and implantation.

    • Nicolas C. Rivron
    • , Javier Frias-Aldeguer
    •  & Niels Geijsen
  • Article |

    During emergency myelopoiesis in mice, clusters of self-renewing granulocyte/macrophage progenitors (GMP) are transiently formed in the bone marrow cavity to produce a burst of myeloid cells; in leukaemia, GMP clusters persist and constantly generate myeloid leukaemia cells.

    • Aurélie Hérault
    • , Mikhail Binnewies
    •  & Emmanuelle Passegué
  • Article |

    Bone marrow endothelial cells have dual roles in the regulation of haematopoietic stem cell maintenance and in the trafficking of blood cells between the bone marrow and the blood circulatory system; this study shows that these different functions are regulated by distinct types of endothelial blood vessels with different permeability properties, affecting the metabolic state of their neighbouring stem cells.

    • Tomer Itkin
    • , Shiri Gur-Cohen
    •  & Tsvee Lapidot
  • Letter |

    Until recently, complex multi-parameters were required for the isolation and identification of haematopoietic stem cells, complicating study of their biology in situ; here the authors have found that expression of a single gene, Hoxb5, defines haematopoietic stem cells with long-term reconstitution capacity, and that these cells are mainly found in direct contact with endothelial cells.

    • James Y. Chen
    • , Masanori Miyanishi
    •  & Irving L. Weissman
  • Article |

    Haematopoietic stem cells normally reside in a bone marrow niche but they are recruited to the spleen after physiological stresses; here, endothelial cells and stromal cells around sinusoidal blood vessels of the spleen are shown to secrete key niche factors to support this process.

    • Christopher N. Inra
    • , Bo O. Zhou
    •  & Sean J. Morrison
  • Article |

    In the uninjured liver, a population of self-renewing, diploid hepatocytes is identified near the central vein; these cells respond to Wnt signals that are provided by the adjacent central vein endothelial cells, and can give rise to all other hepatocytes to maintain liver homeostasis.

    • Bruce Wang
    • , Ludan Zhao
    •  & Roel Nusse
  • Letter |

    Mouse hair follicles in the skin cycle between growth and regression, while maintaining a pool of stem cells for continued regeneration; here, live imaging is used to show that a combination of niche-induced stem cell apoptosis and epithelial phagocytosis underlies regression, regulating the stem cell pool.

    • Kailin R. Mesa
    • , Panteleimon Rompolas
    •  & Valentina Greco
  • Letter |

    An analysis of mouse skin reveals that super-enhancers are critical to identity, lineage commitment and plasticity of adult stem cells; dynamic super-enhancer remodelling in new niches is dependent on the levels of pioneer transcription factor SOX9, which is identified as a key regulator of super-enhancer chromatin for hair follicle stem cells.

    • Rene C. Adam
    • , Hanseul Yang
    •  & Elaine Fuchs
  • Letter |

    Myeloproliferative neoplasms are caused by mutations in the haematopoietic stem cell (HSC) compartment, and here the authors show that the HSC niche contributes to the pathogenesis; sympathetic innervation of mesenchymal stem cells (MSCs) is reduced in the bone marrow of patients, which leads to reduced MSC numbers and increased mutant HSC expansion, and restoring sympathetic regulation of MSCs with neuroprotective/sympathomimetic drugs prevents mutant HSC expansion.

    • Lorena Arranz
    • , Abel Sánchez-Aguilera
    •  & Simón Méndez-Ferrer
  • Article |

    Immunofluorescence imaging and computational modelling are used to study the spatial distribution of different cell types within the haematopoietic stem cell (HSC) niche; findings show that quiescent HSCs associate specifically with small arterioles that are preferentially found in the endosteal bone marrow and are essential in maintaining this quiescence.

    • Yuya Kunisaki
    • , Ingmar Bruns
    •  & Paul S. Frenette
  • Article |

    By combining lineage tracing with intravital microscopy, the position of a stem cell within its extended mouse hair follicle niche is shown to control its long-term fate and behaviour; laser ablation to remove restricted cell populations shows that bulge stem cells are dispensable for hair regeneration, and non-hair epithelial cells may change their fate to compensate and sustain hair growth.

    • Panteleimon Rompolas
    • , Kailin R. Mesa
    •  & Valentina Greco
  • Letter |

    Endogenous prostaglandin E2 (PGE2) is a potent regulator of haematopoietic stem cell (HSC) retention in the bone marrow; inhibition of endogenous PGE2 signalling by non-steroidal anti-inflammatory drugs results in enhanced HSC and haematopoietic progenitor cell mobility via E-prostanoid 4 (EP4) receptor antagonism.

    • Jonathan Hoggatt
    • , Khalid S. Mohammad
    •  & Louis M. Pelus
  • Letter |

    The hilum (a transitional region) of the mouse ovary is identified as a stem cell niche of the ovarian surface epithelium, and its cells are prone to malignant transformation after inactivation of common tumour suppressor genes, suggesting that they may be the origin of ovarian carcinoma.

    • Andrea Flesken-Nikitin
    • , Chang-Il Hwang
    •  & Alexander Yu. Nikitin
  • Article |

    The expression of fibroblast growth factor in aged muscle fibre, the muscle stem cell niche, is shown to cause satellite cells to lose the capacity for self-renewal, and is thus an age-dependent change that directly influences stem cell quiescence and function.

    • Joe V. Chakkalakal
    • , Kieran M. Jones
    •  & Andrew S. Brack
  • Article |

    In the Drosophila testis, IGF-II messenger RNA binding protein (Imp) is shown to promote stem-cell niche maintenance by stabilizing unpaired (upd) RNA; Imp levels decrease in the hub cells of older males, owing to regulation by the microRNA let-7.

    • Hila Toledano
    • , Cecilia D’Alterio
    •  & D. Leanne Jones
  • Letter |

    Multipotent stem cells expressing Lgr5 are known to generate all cell types of the intestinal epithelium (enterocytes, goblet cells, Paneth cells and enteroendocrine cells). A new study shows that Paneth cells have an essential role for intestinal crypt and stem cell maintenance by supplying essential niche signals to the Lgr5-expressing cells.

    • Toshiro Sato
    • , Johan H. van Es
    •  & Hans Clevers
  • Article |

    Age-associated changes in stem cell supportive niche cells are shown to deregulate normal haematopoiesis by causing haematopoietic stem cell dysfunction. Age-dependent defects in niche cells are systemically regulated and can be reversed by exposure to a young circulation or by neutralization of the conserved longevity regulator, insulin-like growth factor-1, in the marrow microenvironment.

    • Shane R. Mayack
    • , Jennifer L. Shadrach
    •  & Amy J. Wagers