Skin stem cells

  • Article |

    Live imaging and single-cell transcriptomics of mouse hair follicles reveal their development from 2D concentric zones in the placode to 3D longitudinal compartments, one of which is a stem cell compartment.

    • Ritsuko Morita
    • , Noriko Sanzen
    •  & Hironobu Fujiwara
  • Article |

    Stress inhibits  hair growth in mice through the release of the stress hormone corticosterone from the adrenal glands, which inhibits the activation of hair follicle stem cells by suppressing the expression of a secreted factor, GAS6, from the dermal niche.

    • Sekyu Choi
    • , Bing Zhang
    •  & Ya-Chieh Hsu
  • Article |

    Single-cell analysis in a mouse model of skin stretching shows that stretching causes a transient expansion bias in a population of epidermal stem cells, which is associated with chromatin remodelling and changes in transcriptional profiles.

    • Mariaceleste Aragona
    • , Alejandro Sifrim
    •  & Cédric Blanpain
  • Article |

    Cell competition in the developing mouse epithelium involves apoptosis and engulfment when the epithelium has only one layer, but switches to involve asymmetric cell division and differentiation of ‘loser’ cells as the epithelium becomes stratified.

    • Stephanie J. Ellis
    • , Nicholas C. Gomez
    •  & Elaine Fuchs
  • Article |

    After acute inflammation, epithelial stem cells retain a memory that accelerates restoration of the skin barrier during subsequent tissue damage, and this enhancement is dependent on the AIM2 inflammasome and its downstream effectors.

    • Shruti Naik
    • , Samantha B. Larsen
    •  & Elaine Fuchs
  • Letter |

    Intravital imaging reveals unanticipated plasticity of adult skin epithelium in mice when faced with mutational or non-mutational insults, and elucidates the dynamic cellular behaviours used for its return to a homeostatic state.

    • Samara Brown
    • , Cristiana M. Pineda
    •  & Valentina Greco
  • Article |

    The protein translation rate is low in tissue stem cells and tumour-initiating cells, and genetically preventing cytosine-5 methylation on transfer RNA in skin tumours is shown to favour the maintenance of a state of translational inhibition in mice, with tumour-initiating cells in this state becoming more sensitive to cytotoxic stress.

    • Sandra Blanco
    • , Roberto Bandiera
    •  & Michaela Frye
  • Letter |

    Mouse hair follicles in the skin cycle between growth and regression, while maintaining a pool of stem cells for continued regeneration; here, live imaging is used to show that a combination of niche-induced stem cell apoptosis and epithelial phagocytosis underlies regression, regulating the stem cell pool.

    • Kailin R. Mesa
    • , Panteleimon Rompolas
    •  & Valentina Greco
  • Letter |

    An analysis of mouse skin reveals that super-enhancers are critical to identity, lineage commitment and plasticity of adult stem cells; dynamic super-enhancer remodelling in new niches is dependent on the levels of pioneer transcription factor SOX9, which is identified as a key regulator of super-enhancer chromatin for hair follicle stem cells.

    • Rene C. Adam
    • , Hanseul Yang
    •  & Elaine Fuchs
  • Letter |

    Fibroblasts constitute the major mesenchymal cell type in the connective tissue and their functions are remarkably diverse: here, by characterising lineages of mouse skin fibroblasts, it is shown that distinct subpopulations contribute to skin development and repair during injury.

    • Ryan R. Driskell
    • , Beate M. Lichtenberger
    •  & Fiona M. Watt
  • Article |

    Whether a single group of stem cells or multiple populations contribute to the homeostasis of the interfollicular epidermis is controversial; here the authors use lineage tracing and mathematical modelling to show that the progenitors that maintain mouse epidermis are underpinned by slow-cycling stem cells that become mobilized on injury.

    • Guilhem Mascré
    • , Sophie Dekoninck
    •  & Cédric Blanpain