Sequencing

Sequencing refers to the techniques used to determine the primary structure of an unbranched biopolymer (DNA, RNA, protein, carbohydrate) resulting in a symbolic linear depiction of the monomeric subunits which summarizes much of the atomic-level structure of the molecule.

Latest Research and Reviews

Research
20 May 2022 | Open Access

No evidence of DUI in the Mediterranean alien species Brachidontes pharaonis (P. Fisher, 1870) despite mitochondrial heteroplasmy
- Marek Lubośny
- , Beata Śmietanka
- & Artur Burzyński
Scientific Reports 12, 8569
Research
20 May 2022 | Open Access

Proof of concept for multiplex amplicon sequencing for mutation identification using the MinION nanopore sequencer
- Whitney Whitford
- , Victoria Hawkins
- & Jessie C. Jacobsen
Scientific Reports 12, 8572
Research
20 May 2022 | Open Access

Super-resolution visualization of chromatin loop folding in human lymphoblastoid cells using interferometric photoactivated localization microscopy
- Zofia Parteka-Tojek
- , Jacqueline Jufen Zhu
- & Yijun Ruan
Scientific Reports 12, 8582
Research
20 May 2022 | Open Access

Automated next-generation profiling of genomic alterations in human cancers

The genomic profiling of tumours has not been widely adopted in the clinic due to technical and practical hurdles. Here, the authors develop PGDx elio tissue complete, a scalable, standardised and FDA-cleared test comprising a targeted gene panel and automated machine-learning analysis, which detects clinically relevant sequence biomarkers in cancer samples.
- Laurel A. Keefer
- , James R. White
- & Mark Sausen
Nature Communications 13, 2830
Research
19 May 2022 | Open Access

Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors
- Jesse R. Willis
- , Ester Saus
- & Toni Gabaldón
npj Biofilms and Microbiomes 8, 38
Research
19 May 2022 | Open Access

Metagenomic, (bio)chemical, and microscopic analyses reveal the potential for the cycling of sulfated EPS in Shark Bay pustular mats
- Emilie J. Skoog
- , Kelsey R. Moore
- & Tanja Bosak
ISME Communications 2, 43

All Research & Reviews

News and Comment

Research Highlights | 16 May 2022

Genomic outbreak surveillance in resource-poor settings

Lillian Musila highlights a paper by Quick et al., which reported the use of portable nanopore sequencing for on-site, real-time genomic surveillance during the 2014–2016 Ebola virus epidemic.
- Lillian Musila
Nature Reviews Genetics, 1
Research Highlights | 11 May 2022

Cell-free DNA cues for gene expression

Cell-free DNA ‘fragmentomics’ empowers cancer detection and classification.
- Lin Tang
Nature Methods 19, 519
Research Highlights | 11 May 2022

Spatial CRISPR screens in tumors

Perturb-map combines multiplex imaging and spatial transcriptomics to dissect complex biological functions from CRISPR screens in tumor tissues.
- Lei Tang
Nature Methods 19, 517
Comments & Opinion | 09 May 2022

Promoting the genomic revolution in Africa through the Nigerian 100K Genome Project

To leverage the genetic diversity in Nigeria, we established the Non-Communicable Diseases Genetic Heritage Study (NCD-GHS) consortium to help produce a comprehensive catalog of human genetic variation in Nigeria and assess the burden and etiological characteristics of non-communicable diseases in 100,000 adults in Nigeria.
- Segun Fatumo
- , Aminu Yakubu
- & Abasi Ene-Obong
Nature Genetics 54, 531-536
Correspondence | 04 May 2022

Best practices for reporting throughput in biomedical research
- Maik Herbig
- , Akihiro Isozaki
- & Keisuke Goda
Nature Methods, 1-2
Research Highlights | 29 April 2022

The final pieces of the human genome

In six new studies published in Science, the Telomere-to-Telomere (T2T) Consortium reports the assembly and initial characterization of the final, previously unresolved 8% of the human genome.
- Michael Attwaters
Nature Reviews Genetics 23, 321

All News & Comment

Sequencing

Latest Research and Reviews

No evidence of DUI in the Mediterranean alien species Brachidontes pharaonis (P. Fisher, 1870) despite mitochondrial heteroplasmy

Proof of concept for multiplex amplicon sequencing for mutation identification using the MinION nanopore sequencer

Super-resolution visualization of chromatin loop folding in human lymphoblastoid cells using interferometric photoactivated localization microscopy

Automated next-generation profiling of genomic alterations in human cancers

Citizen-science reveals changes in the oral microbiome in Spain through age and lifestyle factors

Metagenomic, (bio)chemical, and microscopic analyses reveal the potential for the cycling of sulfated EPS in Shark Bay pustular mats

News and Comment

Genomic outbreak surveillance in resource-poor settings

Cell-free DNA cues for gene expression

Spatial CRISPR screens in tumors

Promoting the genomic revolution in Africa through the Nigerian 100K Genome Project

Best practices for reporting throughput in biomedical research

The final pieces of the human genome

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