Saccharomyces cerevisiae

Saccharomyces cerevisiae, commonly known as baker’s or brewer’s yeast, is a unicellular fungus and a classic model organism used extensively for research in genetics and molecular biology. It is also used for the industrial production of some biopharmaceuticals.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    A recent study re-casts proteomic analyses as a DNA sequencing problem; by fusing in vivo-expressed proteins to their encoding mRNA, molecular interactions can be identified and quantified through high-throughput nucleic-acid sequencing.

    • Linda Koch
  • Research Highlights |

    A study reports on the suitability of the yeast Saccharomyces cerevisiae as a platform for the assembly and maintenance of diverse RNA virus genomes, including SARS-CoV-2.

    • Linda Koch
  • Research Highlights |

    The elimination of all cross-talk in a signaling pathway turns a yeast cell into a model cell that can sense and report on metabolites.

    • Nicole Rusk
    Nature Methods 16, 457
  • News & Views |

    Mitochondria are critical for cellular energy generation and house oxidative phosphorylation (OXPHOS) complexes, which are under dual genetic control. A study finds that transcript translation and complex assembly are partitioned, and OXPHOS complexes III, IV and V are built at spatially defined regions of the mitochondrial inner membrane.

    • Luke E. Formosa
    •  & Michael T. Ryan
    Nature Cell Biology 20, 511-513
  • Comments & Opinion |

    The commonly used budding yeast strain W303 carries a mutant RAD5 gene (rad5-535), but numerous laboratories use a strain corrected for the mutation. This has resulted in different phenotypes of W303 cells in similar experiments. Here, we aim to raise awareness of the issue to ensure data reproducibility and interpretation.

    • Menattallah Elserafy
    •  & Sherif F. El-Khamisy