Rheumatic diseases

  • Article |

    The transcription factor PU.1 is an essential regulator of the pro-fibrotic gene expression program in fibroblasts; PU.1 expression is upregulated in various fibrotic diseases, whereas inactivation of PU.1 induces regression of fibrosis in a number of organs.

    • Thomas Wohlfahrt
    • , Simon Rauber
    •  & Andreas Ramming
  • Article |

    Semaphorin 3A (Sema3A) is shown to function as a protector of bone, by synchronously inhibiting osteoclastic bone resorption and promoting osteoblastic bone formation.

    • Mikihito Hayashi
    • , Tomoki Nakashima
    •  & Hiroshi Takayanagi