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A retrovirus is an infectious agent belonging to the RNA virus family Retroviridae. These viruses encode a reverse transcriptase enzyme that converts the RNA genome into DNA during the retroviral life cycle, which then becomes integrated into the host genome.
A single dose of a broadly neutralizing, HIV-specific antibody transiently reduces viral load in plasma, and in some individuals is associated with durable virus suppression in the absence of antiretroviral therapy.
Human T-cell lymphotropic virus type 1 (HTLV-1) is an oncogenic deltaretrovirus. Here the authors provide structural characterization of the binding mechanism of novel integrase strand transfer inhibitor (INSTI) candidates to limit HTLV-1 infection.