Respiratory tract diseases

  • Letter |

    The airway mucin Muc5b (but not Muc5ac) is required for mucociliary clearance, defence against bacterial infection in the airways and middle ear, and maintenance of immune homeostasis in the lungs; Muc5b deficiency causes accumulation of apoptotic macrophages, impairment of phagocytosis and reduced production of interleukin-23, leading to infection and inflammation.

    • Michelle G. Roy
    • , Alessandra Livraghi-Butrico
    •  & Christopher M. Evans
  • Letter |

    In a porcine cystic fibrosis model, lack of cystic fibrosis transmembrane conductance regulator (CFTR) is shown to result in acidification of airway surface liquid (ASL), and this decrease in pH reduces the ability of ASL to kill bacteria; the findings directly link loss of the CFTR anion channel to impaired defence against bacterial infection.

    • Alejandro A. Pezzulo
    • , Xiao Xiao Tang
    •  & Joseph Zabner