Quiescence

  • Article |

    Stress inhibits  hair growth in mice through the release of the stress hormone corticosterone from the adrenal glands, which inhibits the activation of hair follicle stem cells by suppressing the expression of a secreted factor, GAS6, from the dermal niche.

    • Sekyu Choi
    • , Bing Zhang
    •  & Ya-Chieh Hsu
  • Letter |

    Here, DNA damage is shown to occur as a direct consequence of inducing haematopoietic stem cells to exit quiescence in response to conditions of stress; in mice with mutations modelling those seen in Fanconi anaemia, this leads to a complete collapse of the haematopoietic system.

    • Dagmar Walter
    • , Amelie Lier
    •  & Michael D. Milsom
  • Article |

    This study shows that ageing satellite cells undergo an irreversible transition from a quiescent to a pre-senescent state that results in the loss of muscle regeneration in sarcopenia; furthermore, increased expression of p16INK4a is identified as a common feature of senescent satellite cells.

    • Pedro Sousa-Victor
    • , Susana Gutarra
    •  & Pura Muñoz-Cánoves
  • Article |

    A new method to trace the lineage of slow cycling label-retaining cells (LRCs) in vivo identifies a population of LRCs that have features of committed Paneth cells but still express stem-cell markers such as Lgr5; the slow cycling cells differentiate into Paneth cells without cell division, but after injury can also repopulate the stem-cell niche and contribute to the regeneration of all intestinal lineages.

    • Simon J. A. Buczacki
    • , Heather Ireland Zecchini
    •  & Douglas J. Winton