Oncostatin M

Oncostatin M is a secreted cytokine, and is related to leukaemia inhibitory factor. Oncostatin M functions in differentiation and development of various cell lineages, cell proliferation, and haematopoiesis. The transmembrane receptor for Oncostatin M on responding cells is a heterodimer between the glycoprotein gp130 and either CD118/LIFR or OSMR.

Latest Research and Reviews

Research
10 August 2021 | Open Access

Bioactive recombinant human oncostatin M for NMR-based screening in drug discovery
- Olga A. Mass
- , Joseph Tuccinardi
- & Lisa R. Warner
Scientific Reports 11, 16174
Research
13 August 2020 | Open Access

The methylation status of the chemerin promoter region located from − 252 to + 258 bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels
- Kamila Kwiecien
- , Piotr Brzoza
- & Mateusz Kwitniewski
Scientific Reports 10, 13702
Research
23 September 2019 | Open Access

Prokaryotic soluble overexpression and purification of oncostatin M using a fusion approach and genetically engineered E. coli strains
- Minh Tan Nguyen
- , Musharrat Jahan Prima
- & Han Choe
Scientific Reports 9, 13706
Research
14 February 2019 | Open Access

Oncostatin M exerts a protective effect against excessive scarring by counteracting the inductive effect of TGFβ1 on fibrosis markers
- Vincent Huguier
- , Jean-Philippe Giot
- & Laure Favot
Scientific Reports 9, 2113
Reviews | 25 September 2018

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

This Review considers the key roles of the IL-6 cytokine family in regulating innate and adaptive immunity, as well as other physiological responses. The authors highlight the potential of targeting IL-6 family members to treat inflammatory diseases and cancer.
- Simon A. Jones
- & Brendan J. Jenkins
Nature Reviews Immunology 18, 773-789
Research | 16 June 2014

Oncostatin M overexpression induces matrix deposition, STAT3 activation, and SMAD1 Dysregulation in lungs of fibrosis-resistant BALB/c mice
- Steven Wong
- , Fernando M Botelho
- & Carl D Richards
Laboratory Investigation 94, 1003-1016

All Research & Reviews

News and Comment

Research Highlights | 26 April 2017

Oncostatin M – a new target in IBD?

Oncostatin M promotes intestinal inflammation and can predict responsiveness to anti-TNF therapy in patients with inflammatory bowel diseases.
- Yvonne Bordon
Nature Reviews Immunology 17, 280

All News & Comment

Oncostatin M

Latest Research and Reviews

Bioactive recombinant human oncostatin M for NMR-based screening in drug discovery

The methylation status of the chemerin promoter region located from − 252 to + 258 bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels

Prokaryotic soluble overexpression and purification of oncostatin M using a fusion approach and genetically engineered E. coli strains

Oncostatin M exerts a protective effect against excessive scarring by counteracting the inductive effect of TGFβ1 on fibrosis markers

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

Oncostatin M overexpression induces matrix deposition, STAT3 activation, and SMAD1 Dysregulation in lungs of fibrosis-resistant BALB/c mice

News and Comment

Oncostatin M – a new target in IBD?

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Oncostatin M

Latest Research and Reviews

Bioactive recombinant human oncostatin M for NMR-based screening in drug discovery

The methylation status of the chemerin promoter region located from − 252 to + 258 bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels

Prokaryotic soluble overexpression and purification of oncostatin M using a fusion approach and genetically engineered E. coli strains

Oncostatin M exerts a protective effect against excessive scarring by counteracting the inductive effect of TGFβ1 on fibrosis markers

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

Oncostatin M overexpression induces matrix deposition, STAT3 activation, and SMAD1 Dysregulation in lungs of fibrosis-resistant BALB/c mice

News and Comment

Oncostatin M – a new target in IBD?

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