Non-coding RNAs

  • Article |

    Small interfering ribonucleic acid (siRNA) is used to silence genes and treat conditions such as human immunodeficiency virus. Safe and efficient delivery, however, is proving problematic. A new class of biologically active siRNA polyelectrolyte complexes based on chemically self-crosslinked siRNA is presented, which shows greatly enhanced gene-silencing efficiencies in vitro and in vivo without significantly eliciting an immune response.

    • Hyejung Mok
    • , Soo Hyeon Lee
    •  & Tae Gwan Park