Next-generation sequencing

In this Tools of the Trade article, Christian Umkehrer describes the development and use of CaTCH, which enables therapy-naive cancer cell clones to be isolated and compared to their resistant counterparts.

Studies have demonstrated the value of genomic analysis for the diagnosis of rare diseases, but accessibility is still in its infancy; global data sharing is needed to further advance our knowledge of all causes of rare disease.

Recent advances in single-cell multiomics have provided holistic views of the multifaceted state of a cell and its interaction with the environment. The rapid development of these technologies has offered a unique opportunity to analyse the molecular and cellular heterogeneity in cancer, and could lead to better cancer diagnosis, treatment and prognosis.

A large-scale genetic sequencing study reveals a potential new therapeutic target in obesity.