Natural product synthesis

Natural product synthesis aims to prepare a complex target molecule such that the product is analytically identical to the naturally occurring compound, termed a natural product. It is used for structure confirmation, but also as a test for new synthetic methodology and sometimes to assist in identifying how the compound is made naturally.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    (−)-Isoscopariusin A is the fourth natural product with potential immunosuppressive activity to be isolated from Isodon scoparius — a plant used in traditional Chinese medicine. Its synthesis will enable further study of its interesting biological activity.

    • Stephen G. Davey
  • News & Views |

    Mimicking biosynthetic pathways can provide access to medicinally important natural products, but generating the reactive species used by nature can often be difficult. Now, a photoredox-based strategy has been developed to access a reactive radical intermediate postulated to be involved in complex lignan biosynthesis.

    • Danny Q. Thach
    •  & Thomas J. Maimone
  • Research Highlights |

    The complete biosynthetic pathway of the anticancer drug etoposide has been engineered into a tobacco plant enabling its direct milligram scale production.

    • Stephen G. Davey
  • News & Views |

    Meroterpenoids are mixed terpenoid–polyketide natural products with a variety of biological activities. Now, a synthetic approach that combines biocatalytic oxidation with a range of other radical-based reactions enables the divergent synthesis of eight oxidized meroterpenoid natural products and one analogue.

    • Andrew Gomm
    •  & Adam Nelson
    Nature Chemistry 12, 109-111
  • Research Highlights |

    An elusive and highly reactive intermediate has been prepared and characterized, ultimately leading to the synthesis of ten natural products.

    • Stephen G. Davey