Morphogenesis is the process by which an organism, tissue or organ develops its shape. Morphogenesis is driven by various cellular and developmental processes including cell proliferation, differentiation, apoptosis, cell migration and cell adhesion.

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News and Comment

  • News & Views |

    Intestinal organoids have been used to model development of the crypt–villus axis and uncover signalling pathways that govern the stem-cell niche and induce differentiation. Two studies now take advantage of intestinal organoids to measure the mechanical forces that drive morphogenesis of the crypt and fate specification of its resident cells.

    • Celeste M. Nelson
    Nature Cell Biology 23, 678-679
  • Research Highlights |

    In this Journal Club, Audrey Williams and Sally Horne-Badovinac highlight the importance of studying the basal cell surface and its dynamics to understand epithelial cell behaviours and tissue rearrangements.

    • Audrey M. Williams
    •  & Sally Horne-Badovinac
  • News & Views |

    Migrasomes are a recently discovered type of extracellular vesicles that are characteristically generated along retraction fibers in migrating cells. Two studies now show how migrasomes are formed and how they function in the physiologically relevant context of the developing zebrafish embryo.

    • Stefania Tavano
    •  & Carl-Philipp Heisenberg
    Nature Cell Biology 21, 918-920
  • News & Views |

    Tissue renewal requires proliferative progenitors with long-lasting potential. Designated stem cells within specialized niches are considered to be the primary mechanism for this requirement. Recent studies show that dispersed equipotent progenitors are sufficient to account for fast-paced cellular dynamics in skin oil glands and foetal gut epithelium.

    • Qing Nie
    •  & Maksim V. Plikus
    Nature Cell Biology 21, 921-923