Model vertebrates

Model vertebrates are extensively studied non-human vertebrates (species with a notochord, or vertebral column) chosen for the ease of investigating particular biological phenomena in areas such as development, physiology or disease. Research on model vertebrates provides insights that are relevant to other organisms, often including humans.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Two microscopy approaches bring flexibility to mesoscopic imaging in the brain, allowing independent imaging in multiple regions simultaneously.

    • Nina Vogt
  • News & Views |

    Optogenetic and thermogenetic tools have been limited to applications for single-state control of cellular processes. A single-component optogenetic tool was found to act as both a temperature sensor and a photoreceptor, enabling multi-state control of developmental signaling.

    • Maxwell Z. Wilson
  • News & Views |

    How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.

    • Severin Mühleder
    •  & Rui Benedito
    Nature Cell Biology 23, 1109-1110
  • Comments & Opinion |

    For over a century, researchers have used mice as models and adapted many new methods to create novel mutations in them. In the past 100+ years, we have gone from breeding strains for selected traits to inducing random mutations throughout the genome to creating designer alleles with multiple functions. Each method offers opportunities and challenges for researchers as they try to address specific research questions with mouse models.

    • Susan M. Bello
    • , Michelle N. Perry
    •  & Cynthia L. Smith
    Lab Animal 50, 263-266