Synthetic chemistry methodology

Synthetic chemistry methodology refers to the methods used for the synthesis of chemical compounds.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    A silicon-linker that tethers a diyne and a diynophile provides new mechanistic insight and control of hexadehydro-Diels–Alder (HDDA) reactions.

    • Colette Whitfield
  • News & Views |

    Aziridines — three-membered nitrogen-containing heterocycles — are important synthetic targets, but N-alkyl aziridines are difficult to synthesize. Now, an electrochemical method, involving a dicationic intermediate, enables the coupling of alkenes and amines.

    • Tiffany Piou
    •  & Louis-Charles Campeau
    Nature Chemistry 13, 1027-1028
  • Research Highlights |

    A geometrically constrained phosphine bearing a tridentate NNS pincer ligand can afford thermoneutral activation of N−H in ammonia.

    • Stacey-Lynn Paiva
  • Research Highlights |

    An article in Nature Chemistry reports a tip-manipulated approach to build custom nanoarchitectures on a surface by activating, orienting and coupling together individual building blocks.

    • Ariane Vartanian
  • News & Views |

    Methods for the synthesis of bicyclo[1.1.1]pentanes (BCPs) typically rely on the release of strain energy, but these routes cannot easily introduce substituents on the BCP bridges. Now, an intramolecular coupling gives access to multi-substituted BCPs, through the synthesis of bridge-substituted bicycloalkyl boronic esters.

    • Cara E. Brocklehurst
    •  & Edward A. Anderson
    Nature Chemistry 13, 928-930