Synthetic chemistry methodology

Synthetic chemistry methodology refers to the methods used for the synthesis of chemical compounds.

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Latest Research and Reviews

News and Comment

  • Comments & Opinion |

    The organizing principles of click chemistry help scientists make molecules for a variety of applications. Such democratization of synthesis is challenging and rewarding, as useful simplicity is difficult to achieve. We reflect on this and look forward, hoping to continue to tie the joy of functional discovery to the challenges of synthetic chemistry.

    • M. G. Finn
    • , Hartmuth C. Kolb
    •  & K. Barry Sharpless
  • News & Views |

    Predictably activating C–H and C–C bonds for the synthesis of new materials remains a challenge within the synthetic community. A ternary catalytic dance between radicals, metals and light may unlock this puzzle.

    • Thiago Reschützegger
    • , Thomas Syphan
    •  & Gabriel dos Passos Gomes
    Nature Synthesis 1, 13-15
  • News & Views |

    Late-stage tritiation with high selectivity, isotopic purity and functional-group tolerance is important for the radiolabelling of drug candidates or bioactive compounds. Now, a broadly applicable protocol using aryl thianthrenium salts allows for tritiation of complex molecules by hydrogenolysis via an intermediate cationic palladium complex.

    • Abir Sarbajna
    •  & Viktoria H. Gessner
    Nature Synthesis 1, 16-17
  • News & Views |

    Iterative synthesis can generalize, automate and democratize the molecule-making process. Now, by using a computer algorithm to scan the depths of chemical reactivity space, thousands of iterative ways to make small molecules are discovered.

    • Danielle C. Loving
    •  & Martin D. Burke
    Nature Synthesis 1, 11-12
  • Research Highlights |

    A rearrangement reaction — a classic of traditional organic synthesis — has been applied to a polymer, enabling conversion of a polyester to a vinyl polymer.

    • Stephen G. Davey