Mesenchymal stem cells

  • Article |

    An analysis of skeletal stem cells in mice reveals that bone ageing occurs at the level of local niches affecting skeletal and haematopoietic lineage output, which may influence systemic aspects of multi-organ physiological ageing.

    • Thomas H. Ambrosi
    • , Owen Marecic
    •  & Charles K. F. Chan
  • Article |

    The identity of the cells that form the haematopoietic stem cell (HSC) niche in bone marrow has been unclear. These authors identify nestin-expressing mesenchymal stem cells as niche-forming cells. These nestin-expressing cells show a close physical association with HSCs and express high levels of genes involved in HSC maintenance, and their depletion reduces bone marrow homing of haematopoietic progenitors.

    • Simón Méndez-Ferrer
    • , Tatyana V. Michurina
    •  & Paul S. Frenette
  • Letter |

    The retinoblastoma tumour suppressor protein pRb can suppress the activity of certain transcription factors and potentiate the activity of others, and has been shown to affect the differentiation of different cell lineages in vitro. These authors show that the Rb gene has a role in driving bone cell formation or brown adipose tissue formation in vivo.

    • Eliezer Calo
    • , Jose A. Quintero-Estades
    •  & Jacqueline A. Lees