Nature Materials

Inflammation

Article | 11 July 2022

Mechanical checkpoint regulates monocyte differentiation in fibrotic niches

Myelofibrosis causes a pathological remodelling of the bone marrow, which becomes stiffer and more elastic, thus promoting the proliferation of proinflammatory monocytes and their differentiation into dendritic cells.
- Kyle H. Vining
- , Anna E. Marneth
- & David J. Mooney
Article | 22 October 2018

Spatial confinement downsizes the inflammatory response of macrophages

Physical confinement of macrophages is shown to down-regulate pro-inflammatory gene transcription, lowering pro-inflammatory macrophage activation and phagocytic potential.
- Nikhil Jain
- & Viola Vogel

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