Histone post-translational modifications

Histone post-translational modifications are covalent modifications of histones by phosphorylation on serine or threonine residues, methylation on lysine or arginine, acetylation and deacetylation of lysines, ubiquitylation of lysines and sumoylation of lysines. Histone modifications are proposed to affect chromosome structure and function, for instance during transcription and chromatin remodelling processes.

Latest Research and Reviews

News and Comment

  • News & Views |

    Epigenetic barriers need to be surmounted in order to increase the efficiency of cardiac reprogramming. A new study now reports that the histone reader PHF7 enhances cardiac reprogramming via recruiting the chromatin remodelling SWI/SNF complex and key transcription factors to the cardiac super enhancers.

    • Elif Eroglu
    • , John P. Schell
    •  & Kenneth R. Chien
    Nature Cell Biology 23, 440-442
  • News & Views |

    Chromosomal instability (CIN) is a hallmark of malignant evolution that underpins cancer progression and therapeutic evasion. There are few established experimental systems to study CIN and ultimately develop potential therapeutic options. A new study now identifies the MSL chromatin complex as a potential vulnerability against CIN in cancer cells.

    • Ali Motazedian
    •  & Mark A. Dawson
    Nature Cell Biology 23, 295-296
  • News & Views |

    The conserved chromatin remodeller DECREASED IN DNA METHYLATION 1 (DDM1) has long been an enigma given its powerful but likely indirect effect in maintaining plant DNA methylation. In this issue of Nature Cell Biology, Osakabe et al. show that the direct action of DDM1 is deposition of the H2A.W histone variant to silence transposable elements.

    • Paul B. Talbert
    •  & Steven Henikoff
    Nature Cell Biology 23, 297-298