Heart stem cells

  • Article |

    Cardiac stem cell therapy in mouse models of ischaemia–reperfusion injury demonstrates that improvement in heart function is linked to an immune response characterized by the induction of CCR2+ and CX3CR1+ macrophages.

    • Ronald J. Vagnozzi
    • , Marjorie Maillet
    •  & Jeffery D. Molkentin
  • Brief Communications Arising |

    • Jop H. van Berlo
    • , Onur Kanisicak
    •  & Jeffery D. Molkentin
  • Article |

    The secreted factor follistatin-like 1 (FSTL1) becomes undetectable in the epicardium of infarcted hearts; when reconstituted using a collagen patch sutured onto an infarcted heart, FSTL1 can induce cell cycle entry and division of pre-existing cardiomyocytes, thus boosting heart function and survival in mouse and pig models of myocardial infarction.

    • Ke Wei
    • , Vahid Serpooshan
    •  & Pilar Ruiz-Lozano
  • Article |

    Whether or not endogenous c-kit+cells residing within the heart contribute cardiomyocytes during physiological ageing or after injury remains unknown; here, using an inducible lineage tracing system, the c-kit+lineage is shown to generate cardiomyocytes at very low levels, and, by contrast, contributes substantially to cardiac endothelial cell generation.

    • Jop H. van Berlo
    • , Onur Kanisicak
    •  & Jeffery D. Molkentin
  • Letter |

    During normal ageing a low rate of division of pre-existing cardiomyocytes, rather than progenitor cells, is responsible for cardiomyocyte genesis; this process is increased fourfold during myocardial infarction.

    • Samuel E. Senyo
    • , Matthew L. Steinhauser
    •  & Richard T. Lee