Glycobiology

Glycobiology is the study of the structure, biosynthesis and biological functions of carbohydrates.

Latest Research and Reviews

News and Comment

  • Editorial |

    The COVID-19 pandemic has highlighted the importance of methodological advancements in basic biological research. We believe that method development will continue to propel both fundamental and applied studies on SARS-CoV-2 and other pathogens.

    Nature Methods 19, 371-372
  • Comments & Opinion |

    Interactions between carbohydrates and the proteins that bind them (lectins) are often some of the first between a host cell and a viral invader. With its highly glycosylated spike protein, SARS-CoV-2 is no exception. Interrogating glycosylation is vital to understand viral infection, yet it has been a challenge. Improvement in methods ranging from mass spectrometry to glycan arrays and modeling simulations are yielding atomic-level information about the glycans that decorate viruses and host cells alike.

    • Amanda E. Dugan
    • , Amanda L. Peiffer
    •  & Laura L. Kiessling
    Nature Methods 19, 384-387
  • News & Views |

    While investigating sex differences in T cell aging, Mkhikian et al. identified a role for excessive IL-7 signaling and N-glycan branching in age-related T cell dysfunction in women and female mice. These findings point to the increasingly recognized importance of the effects of biological sex on immune aging, and delineate new targetable pathways in age-related immune dysfunction.

    • Cassandra J. McGill
    •  & Bérénice A. Benayoun
    Nature Aging 2, 189-191
  • News & Views |

    Software solutions pGlyco3 and StrucGP both aim to better assign the glycan part of a glycopeptide beyond simple glycosyl composition, but they differ in their strategies, their requirement for a glycan library and their applicability to O-glycopeptides.

    • Kay-Hooi Khoo
    Nature Methods 18, 1457-1458