Genetic interaction

  • Letter |

    Screening pairwise combinations of antibiotics and other drugs against three bacterial pathogens reveals that antagonistic and synergistic drug–drug interactions are specific to microbial species and strains.

    • Ana Rita Brochado
    • , Anja Telzerow
    •  & Athanasios Typas
  • Article |

    ANKRD16 attenuates neurodegeneration induced by a mutation in the editing domain of alanyl tRNA synthetase by directly accepting mis-activated serine from the synthetase before transfer to the tRNA, establishing a new mechanism by which editing defects are prevented.

    • My-Nuong Vo
    • , Markus Terrey
    •  & Susan L. Ackerman
  • Letter |

    Epistasis has rarely been shown among natural polymorphisms in human traits; this research using advanced computation and gene expression data reveals many instances of epistasis between common single nucleotide polymorphisms in humans, with epistasis and the direction of its effect replicating in independent cohorts.

    • Gibran Hemani
    • , Konstantin Shakhbazov
    •  & Joseph E. Powell
  • Letter |

    The role that epistasis — non-additive interactions between alleles — plays in shaping population fitness is investigated in Drosophila melanogaster; the raw material to drive reproductive isolation is found to be segregating contemporaneously within species and does not necessarily require the emergence of incompatible mutations independently derived and fixed in allopatry.

    • Russell B. Corbett-Detig
    • , Jun Zhou
    •  & Julien F. Ayroles
  • Letter |

    A cell-autonomous role for the COUP-TFII transcription factor in prostate cancer cells is identified, in which COUP-TFII inhibits TGF-β signalling by binding to SMAD4; COUP-TFII promotes prostate tumorigenesis and metastasis in a mouse model, and is associated with more aggressive disease in human prostate cancers.

    • Jun Qin
    • , San-Pin Wu
    •  & Sophia Y. Tsai
  • Letter
    | Open Access

    Chromosome conformation capture carbon copy (5C) is used to look at the relationships between functional elements and distal target genes in 1% of the human genome in three dimensions; the study describes numerous long-range interactions between promoters and distal sites that include elements resembling enhancers, promoters and CTCF-bound sites, their genomic distribution and complex interactions.

    • Amartya Sanyal
    • , Bryan R. Lajoie
    •  & Job Dekker
  • Article |

    Local adaptations are often governed by several interacting genes scattered throughout the genome. Here a novel type of multi–locus genetic variation is described that has been maintained within a species over a vast period of time. A balanced unlinked gene network polymorphism is dissected that involves galactose utilization in a close relative of baker's yeast.

    • Chris Todd Hittinger
    • , Paula Gonçalves
    •  & Antonis Rokas