Gammadelta T cells

Gammadelta T cells (γδ T cells) are T cells that express a unique T-cell receptor (TCR) composed of one γ-chain and one δ-chain. Gammadelta T cells are of low abundance in the body, are found in the gut mucosa, skin, lungs and uterus, and are involved in the initiation and propagation of immune responses.

Latest Research and Reviews

News and Comment

  • News & Views |

    Brain tumors respire more oxygen, causing a hypoxic microenvironment that impairs innate γδ T cell–mediated antitumor activity. Reducing oxygen consumption by brain tumors or inhibiting hypoxia-inducible factor-1α in γδ T cells reinvigorates γδ T cell tumor-killing activity, leading to prolonged survival in brain-tumor-bearing mice.

    • Jun Yan
    Nature Immunology 22, 268-269
  • News & Views |

    New research demonstrates that γδ T cells recognize Plasmodium-infected erythrocytes via interaction of the T cell antigen receptor with the phosphoantigen sensor BTN3A1 and subsequently destroy infected cells through either cytotoxic molecule secretion or antibody-dependent phagocytosis.

    • Mitchell N. Lefebvre
    •  & John T. Harty
    Nature Immunology 22, 270-272
  • News & Views |

    Cytokines are well-known mediators of the immune response, but, recently, pleiotropic roles in the central nervous system have started to be uncovered. It is now shown that IL-17 directly modulates fear behavior in mice.

    • Rejane Rua
    •  & Nathalie Pujol
    Nature Immunology 21, 1315-1316
  • Research Highlights |

    A population of meningeal γδ T cells regulates anxiety-like behaviour and threat avoidance in mice through IL-17a production, which signals to neurons in the medial prefrontal cortex.

    • Kirsty Minton
  • News & Views |

    γδ T cells are critical contributors to tissue homeostasis. Recent research identifies an unexpected role for γδ T cell–derived IL-17F in promoting sympathetic innervation and tissue thermogenesis through the induction of the cytokine TGF-β in adipose cells.

    • Maria Ciofani
    Nature Immunology 21, 367-368