Eye diseases

  • Article |

    Retinal pericytes connect via interpericyte tunnelling nanotubes into functional syncytia that regulate microcirculatory blood flow to help to match local blood flow with neuronal activity.

    • Luis Alarcon-Martinez
    • , Deborah Villafranca-Baughman
    •  & Adriana Di Polo
  • Brief Communications Arising |

    • Yizhi Liu
    • , David Granet
    •  & Kang Zhang
  • Letter |

    A protocol has been developed to use human induced pluripotent stem cells to obtain a self-formed ectodermal autonomous multizone, which includes distinct cell lineages of the eye, including the ocular surface ectoderm, lens, neuro-retina, and retinal pigment epithelium that can be expanded to form a functional corneal epithelium when transplanted to an animal model of corneal visual impairment.

    • Ryuhei Hayashi
    • , Yuki Ishikawa
    •  & Kohji Nishida
  • Letter |

    Exploring the genetic basis of congenital cataracts in two families identifies a molecule, lanosterol, which prevents intracellular protein aggregation of various cataract-causing mutant crystallins, and which can reduce cataract severity and increase lens transparency in vivo in dogs.

    • Ling Zhao
    • , Xiang-Jun Chen
    •  & Kang Zhang
  • Letter |

    The loss of limbal stem cells (LSCs) due to injury or disease is one of the leading causes of blindness; here, the ABCB5 protein is identified as a marker of LSCs in mouse and human eye, and shown to be functionally required for LSC maintenance, corneal development and repair.

    • Bruce R. Ksander
    • , Paraskevi E. Kolovou
    •  & Natasha Y. Frank