Experimental organisms

Experimental organisms are non-human organisms that can be studied or manipulated in a controlled setting, typically a laboratory.

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Latest Research and Reviews

News and Comment

  • News & Views |

    How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.

    • Severin Mühleder
    •  & Rui Benedito
    Nature Cell Biology 23, 1109-1110
  • Comments & Opinion |

    For over a century, researchers have used mice as models and adapted many new methods to create novel mutations in them. In the past 100+ years, we have gone from breeding strains for selected traits to inducing random mutations throughout the genome to creating designer alleles with multiple functions. Each method offers opportunities and challenges for researchers as they try to address specific research questions with mouse models.

    • Susan M. Bello
    • , Michelle N. Perry
    •  & Cynthia L. Smith
    Lab Animal 50, 263-266
  • Comments & Opinion |

    How to adjust metabolic rate (MR) in mice that differ in body mass and composition continues to lead to controversies. Here, the challenges that reside in the analysis of mouse MR are highlighted to spur consensus on the unequivocal use of regression-based analysis to maximize reliability and relevance of conclusions.

    • Timo D. Müller
    • , Martin Klingenspor
    •  & Matthias H. Tschöp
    Nature Metabolism 3, 1134-1136