Endocrine system and metabolic diseases

Endocrine systems and metabolic diseases affect the endocrine system and disrupt metabolism. Examples include diabetes and goiter.

Featured

News & Views | 18 May 2022

Maternal enzyme reprograms paternal DNA for healthy offspring
- Yumiko K. Kawamura
- & Antoine H. F. M. Peters
Nature
News & Views | 12 May 2022

A new class of drug in the diabetes toolbox
- Klara R. Klein
- & John B. Buse
Nature Medicine 28, 901-902
News & Views | 09 May 2022

Visualizing heterogeneity in type 2 diabetes phenotype, outcome and drug response

Nature Medicine 28, 909-910

Latest Research and Reviews

Research
18 May 2022 | Open Access

Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices
- Jessica Perugini
- , Eleonora Di Mercurio
- & Antonio Giordano
Scientific Reports 12, 8331
Reviews | 18 May 2022

Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions

Glucocorticoid therapies are widely used to treat acute and chronic inflammatory diseases, yet these drugs induce adverse metabolic effects. This Review highlights new insights into mechanisms of glucocorticoid-induced diabetes mellitus and discusses current and future therapeutic options.
- Jia-Xu Li
- & Carolyn L. Cummins
Nature Reviews Endocrinology, 1-18
Research
18 May 2022 | Open Access

Population-based study for the comorbidities and associated factors in Ménière’s disease
- Min Hee Kim
Scientific Reports 12, 8266
Research | 18 May 2022

Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency

Pregestational hyperglycaemia in mothers increases the probability of glucose intolerance in the offspring, an effect controlled by TET3-dependent DNA demethylation of genes involved in insulin secretion.
- Bin Chen
- , Ya-Rui Du
- & Hefeng Huang
Nature, 1-6
Research
18 May 2022 | Open Access

Obesity and accelerated epigenetic aging in a high-risk cohort of children
- Laura Etzel
- , Waylon J. Hastings
- & Idan Shalev
Scientific Reports 12, 8328
Research
18 May 2022 | Open Access

IL-1R-IRAKM-Slc25a1 signaling axis reprograms lipogenesis in adipocytes to promote diet-induced obesity in mice

TLRs/IL-1R signaling play a role in high-fat diet induced adipose tissue dysfunction and obesity-associated metabolic syndrome. Here the authors report that adipocyte-specific deficiency of IL-1 Receptor-Associated Kinase M (IRAKM) ameliorates diet induced obesity, potentially via the mitochondrial citrate carrier Slc25a1 and reduced de novo lipogenesis.
- Weiwei Liu
- , Hao Zhou
- & Xiaoxia Li
Nature Communications 13, 2748

All Research & Reviews

News and Comment

News & Views | 18 May 2022

Maternal enzyme reprograms paternal DNA for healthy offspring

It emerges that high blood sugar deregulates the enzyme TET3 in the eggs of female mice, preventing it from properly modifying sperm-derived DNA when eggs are fertilized. This leads to metabolic defects in adult progeny.
- Yumiko K. Kawamura
- & Antoine H. F. M. Peters
Nature
Research Highlights | 17 May 2022

GIP–GLP1 receptor agonist shows promise
- Shimona Starling
Nature Reviews Endocrinology, 1
Comments & Opinion | 16 May 2022

Progress in islet transplantation is more important than ever

It is increasingly clear that pancreatic islet replacement is needed to provide a comprehensive treatment for the growing numbers of patients with type 1 diabetes mellitus. Advances from the past year suggest that this goal might now be within reach.
- Stefan R. Bornstein
- , Barbara Ludwig
- & Charlotte Steenblock
Nature Reviews Endocrinology, 1-2
Comments & Opinion | 13 May 2022

Weight stigma in healthcare settings is detrimental to health and must be eradicated

A large body of indisputable evidence shows that a certain treatment, commonly advocated by all healthcare professionals for a highly prevalent chronic medical condition, is associated with detrimental effects on health and an increased risk of mortality. This ‘treatment’, which needs eradicating from healthcare settings, is weight stigma.
- Rachel L. Batterham
Nature Reviews Endocrinology, 1-2
News & Views | 12 May 2022

A new class of drug in the diabetes toolbox

The DAWN and SEED trials demonstrate the potential of glucokinase activators for the treatment of type 2 diabetes, but how they fit in the overall treatment algorithm remains to be determined.
- Klara R. Klein
- & John B. Buse
Nature Medicine 28, 901-902
Research Highlights | 10 May 2022

Unravelling adipose tissue fibrosis in obesity
- Shimona Starling
Nature Reviews Endocrinology, 1

All News & Comment

Endocrine system and metabolic diseases

Featured

Maternal enzyme reprograms paternal DNA for healthy offspring

A new class of drug in the diabetes toolbox

Visualizing heterogeneity in type 2 diabetes phenotype, outcome and drug response

Latest Research and Reviews

Ciliary neurotrophic factor is increased in the plasma of patients with obesity and its levels correlate with diabetes and inflammation indices

Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions

Population-based study for the comorbidities and associated factors in Ménière’s disease

Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency

Obesity and accelerated epigenetic aging in a high-risk cohort of children

IL-1R-IRAKM-Slc25a1 signaling axis reprograms lipogenesis in adipocytes to promote diet-induced obesity in mice

News and Comment

Maternal enzyme reprograms paternal DNA for healthy offspring

GIP–GLP1 receptor agonist shows promise

Progress in islet transplantation is more important than ever

Weight stigma in healthcare settings is detrimental to health and must be eradicated

A new class of drug in the diabetes toolbox

Unravelling adipose tissue fibrosis in obesity

Quick links

Discover content

Publishing policies

Author & Researcher services

Libraries & institutions

Advertising & partnerships

Career development

Regional websites

Legal & Privacy

Endocrine system and metabolic diseases

Featured

Related Subjects

Latest Research and Reviews

News and Comment

Search

Quick links