DNA nanotechnology

  • Letter |

    A set of 355 self-assembling DNA ‘tiles’ can be reprogrammed to implement many different computer algorithms—including sorting, palindrome testing and divisibility by three—suggesting that molecular self-assembly could be a reliable algorithmic component in programmable chemical systems.

    • Damien Woods
    • , David Doty
    •  & Erik Winfree
  • Letter |

    By using DNA sequence information to encode the shapes of DNA origami building blocks, shape-programmable assemblies can be created, with sizes and complexities similar to those of viruses.

    • Klaus F. Wagenbauer
    • , Christian Sigl
    •  & Hendrik Dietz
  • Letter |

    All necessary strands for DNA origami can be created in a single scalable process by using bacteriophages to generate single-stranded precursor DNA containing the target sequences interleaved with self-excising DNA enzymes.

    • Florian Praetorius
    • , Benjamin Kick
    •  & Hendrik Dietz
  • Letter |

    The incorporation of large numbers of chemically diverse functional components into microfabricated structures at precise locations is challenging; now the precision placement of DNA origami by directed self-assembly is shown to overcome this problem for the purpose of reliably and controllably coupling molecular emitters to photonic crystal cavities.

    • Ashwin Gopinath
    • , Evan Miyazono
    •  & Paul W. K. Rothemund
  • Letter |

    Probing the assembly process that occurs when single-stranded DNA is folded into desired shapes by ‘DNA origami’ shows that it can be guided by controlling the strengths of local and long-range interactions, enabling more reproducible synthesis.

    • Katherine E. Dunn
    • , Frits Dannenberg
    •  & Jonathan Bath
  • Letter |

    A general method of folding arbitrary polygonal digital meshes in DNA uses a routeing algorithm based on graph theory and a relaxation simulation that traces scaffold strands through the target structures to produce complex structures with an open conformation that are stable under biological assay conditions.

    • Erik Benson
    • , Abdulmelik Mohammed
    •  & Björn Högberg
  • Letter |

    An efficient and scalable strategy with robust error correction is reported for encoding a record amount of information (including images, text and audio files) in DNA strands; a ‘DNA archive’ has been synthesized, shipped from the USA to Germany, sequenced and the information read.

    • Nick Goldman
    • , Paul Bertone
    •  & Ewan Birney