Differentiation

Cell differentiation is the process by which specialised cells such as muscle, skin or nerve cells, are formed from less specialised cells such as stem cells and their progenitors. Differentiation occurs during development of an organism to produce new specialised cells, and also in adults to replenish cells that are lost.

Latest Research and Reviews

News and Comment

  • News & Views |

    With advanced high-throughput technologies, scientists can now use transcriptional signatures to study melanocytes as they become cancer. A new study identifies transcriptional programs at single-cell resolution across platforms and species, which enables prediction of melanoma prognosis and response to immune-checkpoint inhibitor therapy.

    • Alicia M. McConnell
    •  & Leonard I. Zon
    Nature Cell Biology 23, 930-931
  • Research Highlights |

    Morral, Stanisavljevic et al. show that colorectal cancer (CRC) cell hierarchy is based on the capacity to perform biosynthesis. Undifferentiated CRC cells that have high capacity for protein synthesis were found immediately adjacent to the stroma, and this capacity was lost upon differentiation.

    • Ulrike Harjes