Combinatorial libraries

Combinatorial libraries are collections of chemical compounds, small molecules or macromolecules such as proteins, synthesized by combinatorial chemistry, in which multiple different combinations of related chemical species are reacted together in similar chemical reactions. Chemical synthesis methods are used to generate large groups of compounds that can themselves be elaborated in a similar combinatorial fashion.

Latest Research and Reviews

News and Comment

  • News & Views |

    Phage display enables screening of billions of peptides comprised mainly of natural amino acids. Now, a method to attach and encode a range of structurally diverse compounds has been reported. This method can expand the chemical space covered by phage display peptide libraries.

    • Christian Heinis
    Nature Chemistry 13, 512-513
  • News & Views |

    Directed evolution on the yeast cell surface enables the discovery of sortase variants with altered specificity capable of modifying Aβ peptides under physiologically relevant conditions.

    • James A. Van Deventer
  • News & Views |

    High-throughput screening of solvothermal crystallization conditions for MOFs and other solids may receive a boost from the application of 3D printing techniques to low-cost, disposable pressure vessels.

    • Ian D. Williams
    Nature Chemistry 6, 953-954
  • News & Views |

    A high-throughput approach combining combinatorial deposition of materials with parallel blow-forming speeds up the discovery rate of bulk metallic glasses that can be easily formed into complex shapes.

    • Dan B. Miracle
    Nature Materials 13, 432-433
  • News & Views |

    Systems biology methods accumulate a vast array of information to generate hypotheses and discover new cellular relationships. A combination of 'omics' technologies now provides important proof of biochemical predictions and creates new opportunities for understanding cellular functional architecture.

    • Andreas Schmid
    •  & Lars M Blank