CNS cancer

CNS cancer is a type of cancer that forms in the central nervous system. It includes brain stem glioma, craniopharyngioma, medulloblastoma and meningioma.

Latest Research and Reviews

News and Comment

  • News & Views |

    Cerebrospinal fluid liquid biopsies can enable the characterization and monitoring of medulloblastoma. The analysis of copy-number variations in circulating tumour DNA present in these samples can be used as a biomarker to determine the presence of measurable residual disease, and facilitate the optimal treatment and clinical management of patients with medulloblastoma.

    • Joan Seoane
    •  & Laura Escudero
  • News & Views |

    Glioblastoma multiforme (GBM) is a lethal form of primary brain cancer. A new study now implicates beta-secretase 1 (BACE1) as a crucial regulator of pro-tumoral IL-6–STAT3 signaling in GBM-associated macrophages. An effective BACE1 inhibitor, clinically developed for Alzheimer’s disease, may offer new hope for GBM treatment.

    • Amaia Martinez-Usatorre
    •  & Michele De Palma
    Nature Cancer 2, 1119-1121
  • News & Views |

    Pseudouridine is the most abundant RNA modification, but its biological role remains poorly understood. A study now finds dysregulated pseudouridine synthase PUS7 in glioblastoma and demonstrates that pharmacological inhibition of PUS7 leads to reduced tumorigenesis, which underpins the therapeutic potential of targeting epitranscriptomic regulators in cancer.

    • Virginia Morón-Calvente
    •  & Sandra Blanco
    Nature Cancer 2, 876-878