CNS cancer

CNS cancer is a type of cancer that forms in the central nervous system. It includes brain stem glioma, craniopharyngioma, medulloblastoma and meningioma.

Latest Research and Reviews

Reviews
14 May 2022 | Open Access

Targeting the apoptosis pathway to treat tumours of the paediatric nervous system
- Marie-Claire Fitzgerald
- , Philip J. O’Halloran
- & Brona M. Murphy
Cell Death & Disease 13, 460
Research | 11 May 2022

Olfactory sensory experience regulates gliomagenesis via neuronal IGF1

A mouse model of gliomagenesis reveals that olfaction can directly regulate the genesis of gliomas, showing that sensory experience and gliomagenesis are linked and providing insight into the neural circuitry involved.
- Pengxiang Chen
- , Wei Wang
- & Chong Liu
Nature, 1-7
Research
10 May 2022 | Open Access

The genomic and transcriptional landscape of primary central nervous system lymphoma

Primary lymphomas of the central nervous system (PCNSL) are defined as diffuse large B-cell lymphomas (DLBCL) confined to the CNS. Here, the authors complete whole genome sequencing and RNA-seq to characterize 51 PCNSLs, and find common mutations in immune pathways and upregulated TERT expression and find distinct pathway differences between DLBCL and other primary CNS lymphomas.
- Josefine Radke
- , Naveed Ishaque
- & Frank L. Heppner
Nature Communications 13, 2558
Research | 09 May 2022

Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities

DNA methylation profiling of 565 meningiomas highlights three groups associated with distinct molecular, clinical and therapeutic features.
- Abrar Choudhury
- , Stephen T. Magill
- & David R. Raleigh
Nature Genetics 54, 649-659
Research
07 May 2022 | Open Access

Association between microRNAs 10b/21/34a and acute toxicity in glioblastoma patients treated with radiotherapy and temozolomide
- Aleksandar Stepanović
- , Marina Nikitović
- & Nina Petrović
Scientific Reports 12, 7505
Research
02 May 2022 | Open Access

The dual role of glioma exosomal microRNAs: glioma eliminates tumor suppressor miR-1298-5p via exosomes to promote immunosuppressive effects of MDSCs
- Yanhua Qi
- , Chuandi Jin
- & Gang Li
Cell Death & Disease 13, 426

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News and Comment

News & Views | 11 April 2022

Towards personalizing radiotherapy for brain metastasis

Secretion of S100A9 by brain metastatic cells activates radioresistance. Blood S100A9 could be used as a biomarker to predict responses to irradiation and to guide a combination therapy with a radiosensitizer.

Nature Medicine 28, 643-644
News & Views | 15 December 2021

Cerebrospinal fluid liquid biopsies for medulloblastoma

Cerebrospinal fluid liquid biopsies can enable the characterization and monitoring of medulloblastoma. The analysis of copy-number variations in circulating tumour DNA present in these samples can be used as a biomarker to determine the presence of measurable residual disease, and facilitate the optimal treatment and clinical management of patients with medulloblastoma.
- Joan Seoane
- & Laura Escudero
Nature Reviews Clinical Oncology 19, 73-74
News & Views | 22 November 2021

Alzheimer’s drug turns macrophages against cancer

Glioblastoma multiforme (GBM) is a lethal form of primary brain cancer. A new study now implicates beta-secretase 1 (BACE1) as a crucial regulator of pro-tumoral IL-6–STAT3 signaling in GBM-associated macrophages. An effective BACE1 inhibitor, clinically developed for Alzheimer’s disease, may offer new hope for GBM treatment.
- Amaia Martinez-Usatorre
- & Michele De Palma
Nature Cancer 2, 1119-1121
Research Highlights | 13 October 2021

Microglia subset associated with high-grade glioma
- Ian Fyfe
Nature Reviews Neurology 17, 660
News & Views | 23 September 2021

A therapy PUSh for GBM

Pseudouridine is the most abundant RNA modification, but its biological role remains poorly understood. A study now finds dysregulated pseudouridine synthase PUS7 in glioblastoma and demonstrates that pharmacological inhibition of PUS7 leads to reduced tumorigenesis, which underpins the therapeutic potential of targeting epitranscriptomic regulators in cancer.
- Virginia Morón-Calvente
- & Sandra Blanco
Nature Cancer 2, 876-878
Correspondence | 27 July 2021

Insight into the public’s interest in tumour treating fields
- David J. Byun
- , Aram S. Modrek
- & Erik P. Sulman
British Journal of Cancer 125, 901-903

All News & Comment

CNS cancer

Latest Research and Reviews

Targeting the apoptosis pathway to treat tumours of the paediatric nervous system

Olfactory sensory experience regulates gliomagenesis via neuronal IGF1

The genomic and transcriptional landscape of primary central nervous system lymphoma

Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities

Association between microRNAs 10b/21/34a and acute toxicity in glioblastoma patients treated with radiotherapy and temozolomide

The dual role of glioma exosomal microRNAs: glioma eliminates tumor suppressor miR-1298-5p via exosomes to promote immunosuppressive effects of MDSCs

News and Comment

Towards personalizing radiotherapy for brain metastasis

Cerebrospinal fluid liquid biopsies for medulloblastoma

Alzheimer’s drug turns macrophages against cancer

Microglia subset associated with high-grade glioma

A therapy PUSh for GBM

Insight into the public’s interest in tumour treating fields

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