Cell proliferation

  • Article |

    High levels of the sexually dimorphic hormone ecdysone, produced by active ovaries in Drosophila, promote the proliferation of stem cells in the female gut and maximize reproductive fitness, but also increase female susceptibility to age-dependent dysplasia and tumorigenesis.

    • Sara Mahmoud H. Ahmed
    • , Julieta A. Maldera
    •  & Bruce A. Edgar
  • Letter |

    The salamander, or axolotl, is well known to be able to regenerate missing body parts, but the signals that drive the initial proliferative response were unclear; now, a secreted protein has been identified that induces the initial cell cycle response after injury.

    • Takuji Sugiura
    • , Heng Wang
    •  & Elly M. Tanaka
  • Article |

    The morphogen Decapentaplegic (Dpp) has been implicated in both wing patterning and growth in fruitflies; here, a nanobody-based morphotrap approach has been developed that rules out a role for the Dpp gradient in regulating lateral wing growth.

    • Stefan Harmansa
    • , Fisun Hamaratoglu
    •  & Emmanuel Caussinus
  • Article |

    Here, the first genome-wide in vivo RNA interference screens in a mammalian animal model are reported: genes involved in normal and abnormal epithelial cell growth are studied in developing skin tissue in mouse embryos, and among the findings, β-catenin is shown to act as an antagonist to normal epithelial cell growth as well as promoting oncogene-driven growth.

    • Slobodan Beronja
    • , Peter Janki
    •  & Elaine Fuchs
  • Letter |

    The Drosophila tumour suppressors Scribbled and Discs large 1 are found to be essential regulators of planar spindle alignment during epithelial cell division; aberrant effects of spindle alignment are shown to be corrected through apoptosis, and the suppression of this mechanism can result in epithelial dysplasia and tumorigenesis.

    • Yu-ichiro Nakajima
    • , Emily J. Meyer
    •  & Matthew C. Gibson
  • Article |

    Whether a single group of stem cells or multiple populations contribute to the homeostasis of the interfollicular epidermis is controversial; here the authors use lineage tracing and mathematical modelling to show that the progenitors that maintain mouse epidermis are underpinned by slow-cycling stem cells that become mobilized on injury.

    • Guilhem Mascré
    • , Sophie Dekoninck
    •  & Cédric Blanpain
  • Letter |

    Sequence variations in a 58-kilobase interval on human chromosome 9p21 have been associated with an increased risk of coronary artery disease. However, this interval contains no protein-coding genes and the mechanism underlying the increased risk has been unclear. Here, the corresponding interval has been deleted from mouse chromosome 4, revealing that this part of the chromosome regulates the cardiac expression of two nearby genes, Cdkn2a and Cdkn2b, and the proliferation dynamics of vascular cells.

    • Axel Visel
    • , Yiwen Zhu
    •  & Len A. Pennacchio