Cell lineage

A recent study reports the development of Stereo-seq (spatial enhanced resolution omics-sequencing) and its application to generate a spatiotemporal transcriptomic atlas of mouse organogenesis.

Facchinello, Astone et al. demonstrate a role for the endothelial oxidative pentose phosphate pathway (oxPPP) in promoting vascular mural cell coverage and maturation during early development by regulating elastin expression. This mechanism establishes a critical role for oxPPP in the formation of the vascular system.

A study in Nature Genetics applies whole-genome sequencing to monozygotic twins, their parents, partners and offspring to identify and characterize early developmental mutations, as well as the fate of mutated cells.

A recent study combines CRISPR-based perturbation with single-cell RNA sequencing to characterize the roles of epigenome regulator proteins in controlling cell fate and identity during embryonic development.

A study in Science describes the generation of a lineage-resolved single-cell transcriptome atlas for Caenorhabditis elegans embryos. This resource provides insight into the transcriptional changes underlying cell fate decisions.