Cancer epigenetics

Cancer epigenetics is the study of somatically heritable changes to molecular processes that influence the flow of information between the DNA of cancer cells and their gene expression patterns. This includes comparative (tumour cell versus normal cell) investigation of nuclear organization, DNA methylation, histone modification and the consequences of genetic mutations in genes encoding epigenetic regulators.

Latest Research and Reviews

News and Comment

  • News & Views |

    Enhancer of zeste homolog 2 (EZH2) has been shown to promote development of castration-resistant prostate cancer (CRPC) through various mechanisms. A new study now shows that a phosphorylated EZH2 interacts with the androgen receptor (AR) and reprograms AR transcriptional activity to facilitate transition of CRPC into a lineage infidelity state.

    • Li Xin
    Nature Cell Biology 23, 934-936
  • News & Views |

    LKB1 is frequently mutated in lung, cervical and other types of cancers. To determine how LKB1 inactivation contributes to lung cancer progression, Pierce et al. employed a chromatin accessibility assay to reveal Sox17 as a key transcription factor downstream of LKB1, promoting lung cancer metastasis.

    • Skirmantas Kriaucionis
    Nature Cell Biology 23, 816-817
  • Comments & Opinion |

    A systematic approach to understanding the noncoding genome in cancer promises to improve cancer diagnosis and therapy. New technologies and bold therapeutic approaches are paving the way to truly envisage personalized cancer medicine in the future.

    • Howard Y. Chang
    Nature Reviews Cancer 21, 609-610