Biopolymers in vivo

  • Article |

    The basement membrane stiffness is shown to be a more dominant determinant than pore size in regulating cancer cell invasion, metastasis formation and patient survival. This stiffness is now known to be affected by the ratio of netrin-4 to laminin, with more netrin-4 leading to softer basement membranes.

    • Raphael Reuten
    • , Sina Zendehroud
    •  & Janine T. Erler