Biomimetic synthesis

Biomimetic synthesis is a branch of natural product synthesis that aims to synthesize a target molecule through a series of reactions, and passing through intermediate structures, that are closely related to those that occur during biosynthesis in its natural source.

Latest Research and Reviews

News and Comment

  • Editorial |

    There are many unanswered questions regarding how the biomolecules and biomechanical processes that define life came to be. A collection of Articles in this issue show how intermediates in RNA synthesis might have formed and how the initiation and evolution of RNA replication might have occurred.

  • News & Views |

    Nature oxidizes biosynthetic intermediates into structurally and functionally diverse peptides. An iron-catalysed C–H oxidation mimics this approach in the lab, enabling chemists to synthesize structural analogues with ease.

    • Sean Bartlett
    •  & David R. Spring
  • News & Views |

    The ability of enzymes to direct the synthesis of complex natural products from simple starting materials is epitomized by terpene biosynthesis. Now, a supramolecular catalyst has been shown to mimic some of the reactivity of this process.

    • Jeremy J. Roach
    •  & Ryan A. Shenvi
    Nature Chemistry 7, 187-189