Biomaterials

Biomaterials are those materials — be it natural or synthetic, alive or lifeless, and usually made of multiple components — that interact with biological systems. Biomaterials are often used in medical applications to augment or replace a natural function.

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Latest Research and Reviews

  • Reviews |

    The central nervous system is protected by tightly regulated physiological barriers, which make drug delivery into the brain and spinal cord very challenging. This Review discusses the pathophysiological changes that complicate drug delivery into the central nervous system and examines materials-based strategies to bypass or overcome these barriers for drug delivery.

    • Elizabeth Nance
    • , Suzie H. Pun
    •  & Drew L. Sellers
  • Research
    | Open Access

    Cellulose chains with a reducing-end thiol group are of interest to install a controllable topochemical pattern of site-selective modification into nanocellulose materials. Selection of the polymerizing enzyme (cellodextrin phosphorylase; CdP) was pursued here to enhance the synthetic precision in the preparation of 1-thio-cellulose. The CdP from Clostridium stercorarium (CsCdP) was identified as a practical catalyst for 1-thio-cellulose synthesis in high purity (≥95%) directly from β-1-thio-glucose. The synthesis proceeds without the need of cellobiose phosphorylase (CbP) and minimizes the contamination (plain cellulose; ≤5%) in the product.

    • Chao Zhong
    •  & Bernd Nidetzky
  • Research |

    Using a facile method, a gelatin hydrogel with anisotropic gel properties was prepared on a substrate via hydrogelation to induce self-assembly. Three kinds of surface properties (structural control factors) of the template induce the formation of an anisotropic gelatin network by self-assembly. The swelling behavior and mechanical properties of the anisotropic and isotropic gelatin hydrogels are different. When the hydrogel is compressed in a direction perpendicular to the tube-like gelatin network, the inner space of the network is compressed.

    • Kohei Kawaguchi
    • , Syuuhei Komatsu
    •  & Kazuki Murai
  • Research |

    Water-walking insects harness capillary forces by changing body posture to climb or descend the meniscus between water and a solid object. Now, autonomous aqueous-based synthetic systems have been shown to overcome the meniscus barrier and shuttle cargo subsurface between a landing site and targeted drop-off sites.

    • Ganhua Xie
    • , Pei Li
    •  & Thomas P. Russell

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