Biological sciences

Biological sciences encompasses all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants.

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News & Views | 10 August 2022

A map of the human heart after myocardial infarction

Nature
News & Views | 10 August 2022

Neurons shape the identity of microglia in the brain

Nature
News & Views | 10 August 2022

Unlatching a window into the molecular landscape of prion toxicity
- Jesús R. Requena
Nature Structural & Molecular Biology, 1-2

Latest Research and Reviews

Research
10 August 2022 | Open Access

Multi-omics characterization and therapeutic liability of ferroptosis in melanoma
- Yi He
- , Yu Dong
- & Hong Liu
Signal Transduction and Targeted Therapy 7, 268
Reviews | 10 August 2022

Gene regulation on extrachromosomal DNA

Amplification of oncogene expression through extrachromosomal DNA is a common feature of many cancers and is associated with poor outcomes. Hung et al. review how regulation of extrachromosomal DNA gene expression is linked to alterations in chromatin structure and changes in contacts with DNA regulatory elements.
- King L. Hung
- , Paul S. Mischel
- & Howard Y. Chang
Nature Structural & Molecular Biology, 1-9
Reviews | 10 August 2022

The glymphatic system: implications for drugs for central nervous system diseases

Evidence for a fluid clearance pathway in the central nervous system known as the glymphatic system has grown in the past decade. Nedergaard and colleagues overview the evidence for the glymphatic system and its role in disease, and discuss opportunities to harness the glymphatic system therapeutically; for example, by improving the effectiveness of intrathecally delivered drugs.
- Terhi J. Lohela
- , Tuomas O. Lilius
- & Maiken Nedergaard
Nature Reviews Drug Discovery, 1-17
Research
10 August 2022 | Open Access

mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1

mTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1.
- Stéphanie Kaeser-Pebernard
- , Christine Vionnet
- & Jörn Dengjel
Nature Communications 13, 4685
Research | 10 August 2022

Conformational buffering underlies functional selection in intrinsically disordered protein regions

Foutel et. al. identify conformational buffering as a mechanism for functional selection in intrinsically disordered protein regions that allows robust encoding of a tethering function by a hypervariable disordered linker through compensatory changes in sequence length and composition.
- Nicolás S. González-Foutel
- , Juliana Glavina
- & Lucía B. Chemes
Nature Structural & Molecular Biology, 1-10
Research
10 August 2022 | Open Access

Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus

Neither CDK4/6 inhibitors nor oncolytic adenoviruses show high efficiency as monotherapy in the treatment of cancer. Authors show here that when combined, CDK4/6 inhibitors deplete Retinoblastoma protein levels, which leads to more efficient virus replication and an increase in oncolytic virus-producing cancer cells and thus to efficient anti-tumor response in mouse xenograft sarcoma models.
- Jana Koch
- , Sebastian J. Schober
- & Per Sonne Holm
Nature Communications 13, 4689

All Research & Reviews

News and Comment

Research Highlights | 10 August 2022

‘Poisoning’ of the transcriptome by ultraconserved elements

Leclair and Anczuków describe how high-throughput screens uncovered the connection between poison exons and cancer.
- Nathan K. Leclair
- & Olga Anczuków
Nature Reviews Molecular Cell Biology, 1
Research Highlights | 10 August 2022

How one molecule senses light and temperature
- Sara Osman
Nature Structural & Molecular Biology, 1
Research Highlights | 10 August 2022

Structure of RAS signaling regulator complex reveals mechanism
- Sara Osman
Nature Structural & Molecular Biology, 1
News | 10 August 2022

Why low temperatures could help starve tumours of fuel

Cold exposure in mice activates brown fat to deny tumours glucose, and the future of extreme heatwaves.
- Benjamin Thompson
Nature
Editorial
10 August 2022 | Open Access

Molecular explorations of cancer biology and therapeutics at PDB-101
- David S. Goodsell
- , Shuchismita Dutta
- & Stephen K. Burley
Oncogene, 1-3
News | 10 August 2022

Will ‘Centaurus’ be the next global coronavirus variant? Indian cases offers clues

The BA.2.75 variant is rising fast in the country, but hospitalization rates are low so far.
- Ewen Callaway
Nature

All News & Comment

Biological sciences

Featured

A map of the human heart after myocardial infarction

Neurons shape the identity of microglia in the brain

Unlatching a window into the molecular landscape of prion toxicity

Latest Research and Reviews

Multi-omics characterization and therapeutic liability of ferroptosis in melanoma

Gene regulation on extrachromosomal DNA

The glymphatic system: implications for drugs for central nervous system diseases

mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1

Conformational buffering underlies functional selection in intrinsically disordered protein regions

Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus

News and Comment

‘Poisoning’ of the transcriptome by ultraconserved elements

How one molecule senses light and temperature

Structure of RAS signaling regulator complex reveals mechanism

Why low temperatures could help starve tumours of fuel

Molecular explorations of cancer biology and therapeutics at PDB-101

Will ‘Centaurus’ be the next global coronavirus variant? Indian cases offers clues

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