Latest Research and Reviews

News and Comment

  • News & Views |

    Small-molecule drug discovery and development is limited by the ability of chemists to readily synthesize and purify new compounds with suitable chemical diversity. Now, a new twist on solid-phase chemical synthesis has enabled rapid and simplified synthesis of pharmaceutically relevant small molecules.

    • Mark S. Kerr
    •  & Kevin P. Cole
    Nature Chemistry 13, 399-401
  • News & Views |

    The use of automation for chemical research and reaction discovery has seen significant advances in recent years, but there are still problems that need to be solved. Ella M. Gale and Derek J. Durand discuss limitations in the field and how researchers are working to address these issues.

    • Ella M. Gale
    •  & Derek J. Durand
    Nature Chemistry 12, 509-510
  • Research Highlights |

    Machine learning approaches that attempt to predict the outcome of organic reactions are often complex or highly specialized. A new approach requires the molecular structure of reactants as the only input to predict products, enantioselectivities and yields.

    • Gabriella Graziano
  • News & Views |

    Synthetic organic chemistry is increasingly automated, data rich and intelligent. At the Automated Synthesis Forum, industry and academia showcased their recent progress towards this augmented future.

    • David M. Heard
    •  & Alastair J. J. Lennox
    Nature Chemistry 12, 113-114
  • News & Views |

    Enzymatic approaches to synthesize oligosaccharides offer an alternative to chemical syntheses for the production of homogeneous glycans; however, enzyme-based routes typically require lengthy processes. Now, the design of a water-soluble affinity tag has enabled the automation of multistep enzymatic syntheses of mammalian oligosaccharides.

    • Nicola L. B. Pohl
    Nature Chemistry 11, 201-203