Autoimmunity

Autoimmunity is a process by which the immune system reacts against the body's own tissues. Chronic and/or excessive autoimmune responses can result in autoimmune diseases.

Latest Research and Reviews

Research
11 August 2022 | Open Access

Discovery of anti-Formin-like 1 protein (FMNL1) antibodies in membranous nephropathy and other glomerular diseases
- Maurizio Bruschi
- , Andrea Cavalli
- & Marco Prunotto
Scientific Reports 12, 13659
Research
03 August 2022 | Open Access

Serum levels of IgM to phosphatidylcholine predict the response of multiple sclerosis patients to natalizumab or IFN-β
- Úrsula Muñoz
- , Cristina Sebal
- & Maria Cruz Sádaba
Scientific Reports 12, 13357
Research
30 July 2022 | Open Access

Human umbilical cord mesenchymal stem cells derived extracellular vesicles regulate acquired immune response of lupus mouse in vitro
- Min Xie
- , Cuifang Li
- & Chuan Wen
Scientific Reports 12, 13101
Research
28 July 2022 | Open Access

The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope

In the presence of IFN-γ, a short DRB1*03:01-encoded allelic epitope is found to activate a characteristic lupus transcriptome in macrophages and trigger a cascade of systemic lupus erythematosus-associated cellular aberrations.
- Bruna Miglioranza Scavuzzi
- , Vincent van Drongelen
- & Joseph Holoshitz
Communications Biology 5, 751
Reviews | 20 July 2022

Assessment of disease outcome measures in systemic sclerosis

Assessing systemic sclerosis (SSc) disease activity is challenging, and improved outcome measures are needed. This Review describes clinical and biochemical outcome measures of distinct features of SSc, with an emphasis on the dermatological manifestations and interstitial lung disease, including insights into biomarkers gained from single-cell RNA sequencing.
- Robert Lafyatis
- & Eleanor Valenzi
Nature Reviews Rheumatology, 1-15
Research | 20 July 2022

ADAR1 mutation causes ZBP1-dependent immunopathology

The autoinflammatory pathology associated with alteration of the ZBD domain of the RNA-editing enzyme ADAR1 is driven by signalling that is dependent on the nucleotide sensor ZBP1.
- Nicholas W. Hubbard
- , Joshua M. Ames
- & Andrew Oberst
Nature 607, 769-775

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News and Comment

Research Highlights | 01 August 2022

FOXP3 splice variant is associated with autoimmune disease

New research shows that one of the two main isoforms of the human FOXP3 transcription factor is associated with inflammatory transcriptional regulation and autoimmunity.
- Robert Phillips
Nature Reviews Rheumatology, 1
Comments & Opinion | 15 June 2022

Impaired glucocorticoid receptor expression and mitochondrial metabolism in MDSCs contribute to glucocorticoid resistance in immune thrombocytopenia
- Rick Kapur
Cellular & Molecular Immunology 19, 858-860
News & Views | 09 June 2022

Inching closer to precision treatment for rheumatoid arthritis

Biopsies from synovial joints — and the abundance of B cells and macrophages therein — may instruct more effective treatment decisions for individuals with rheumatoid arthritis.
- Laura T. Donlin
Nature Medicine 28, 1129-1131
Correspondence | 08 June 2022

Dysregulation of IL-34 ligation to SDC-1 mitigates collagen-induced arthritis
- Anja Meyer
- , Ryan Sienes
- & Shiva Shahrara
Cellular & Molecular Immunology, 1-3
Comments & Opinion
30 May 2022 | Open Access

Are BCL6 and EZH2 novel therapeutic targets for systemic lupus erythematosus?
- Shu Ding
- , Yu Rao
- & Qianjin Lu
Cellular & Molecular Immunology 19, 863-865
News & Views | 27 May 2022

Defining an exhaustion-like program that restrains autoreactive CD8⁺ T cells

Intra-islet CD8⁺ T cells from a mouse model of type 1 diabetes exhibit an exhausted phenotype that differs from the canonical T cell exhaustion observed in cancer and chronic viral infection. Deletion of the inhibitory receptor LAG3 in these cells accelerated diabetes incidence and partially reversed this restrained phenotype.

Nature Immunology 23, 832-833

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Autoimmunity

Latest Research and Reviews

Discovery of anti-Formin-like 1 protein (FMNL1) antibodies in membranous nephropathy and other glomerular diseases

Serum levels of IgM to phosphatidylcholine predict the response of multiple sclerosis patients to natalizumab or IFN-β

Human umbilical cord mesenchymal stem cells derived extracellular vesicles regulate acquired immune response of lupus mouse in vitro

The lupus susceptibility allele DRB103:01* encodes a disease-driving epitope

Assessment of disease outcome measures in systemic sclerosis

ADAR1 mutation causes ZBP1-dependent immunopathology

News and Comment

FOXP3 splice variant is associated with autoimmune disease

Impaired glucocorticoid receptor expression and mitochondrial metabolism in MDSCs contribute to glucocorticoid resistance in immune thrombocytopenia

Inching closer to precision treatment for rheumatoid arthritis

Dysregulation of IL-34 ligation to SDC-1 mitigates collagen-induced arthritis

Are BCL6 and EZH2 novel therapeutic targets for systemic lupus erythematosus?

Defining an exhaustion-like program that restrains autoreactive CD8⁺ T cells

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