Asymmetric synthesis

Asymmetric synthesis is a method for preparation of chemical compounds which aims to bias the synthesis in favour of producing one stereoisomer over another stereoisomer. Stereoisomers are molecules with the same connectivity of atoms, but with different arrangements of atoms in three-dimensional space, and can have dramatically different properties from one another.

Latest Research and Reviews

News and Comment

  • News & Views |

    All-carbon quaternary centres are challenging targets in organic synthesis. Now, the development of a zinc-catalysed desymmetrization method enables the synthesis of chiral alcohols with all-carbon quaternary centres by the selective reduction of symmetrical α,α-disubstituted malonates.

    • Jadwiga Gajewy
    •  & Marcin Kwit
    Nature Chemistry 13, 623-624
  • News & Views |

    Tertiary amines are poor directing groups for C(sp3)–H activation using Pdii catalysts due to favourable β-hydride elimination pathways. Now, an N-acetyl amino acid ligand is shown to shut down this deleterious pathway, enabling facile arylation of a highly medicinally relevant group of compounds.

    • Vinod G. Landge
    •  & Michael C. Young
    Nature Chemistry 12, 12-14
  • Comments & Opinion |

    Michelle Francl wonders if a molecule can be just a little bit chiral?

    • Michelle Francl
    Nature Chemistry 11, 597-598
  • News & Views |

    The diversity of engineered amine dehydrogenases for reductive amination remains limited. Now, native amino dehydrogenases offering a different sequence space and catalytic features are discovered — enhancing and broadening the biocatalysis toolbox.

    • Andreas S. Bommarius
    Nature Catalysis 2, 288-289