Asymmetric catalysis

Asymmetric catalysis is a type of catalysis in which a chiral catalyst directs the formation of a chiral compound such that formation of one particular stereoisomer is favoured. Since the catalyst is not consumed in this process it may be used in a substoichiometric quantity – potentially improving efficiency and avoiding waste.

Latest Research and Reviews

News and Comment

  • News & Views |

    The construction of all stereoisomers of molecules containing contiguous stereocentres with full control of the absolute and relative stereochemical configuration has rarely been demonstrated. An approach involving dual-catalytic activation enables the stereodivergent α-propargylation of oxindoles with high stereocontrol and shows broad substrate scope.

    Nature Synthesis 1, 273-274
  • News & Views |

    ‘Solar chemical’ production can be limited by the need for sacrificial reagents, metal-containing catalysts and low product values. Now, H2O2 is generated from H2O and air using lignin as a photocatalyst. Combining lignin with enzymatic catalysis enables selective oxyfunctionalization.

    • Han Sen Soo
    Nature Synthesis 1, 192-193
  • Comments & Opinion
    | Open Access

    The transfer of chiral information from optically pure reaction components to products can generate enantiomerically-enriched molecules, but the control of stereochemistry often proves challenging. Here, the author highlights how our fundamental understanding of stereocontrol has evolved and discusses possible approaches for the rational development of enantioselective catalysts.

    • Jolene P. Reid
  • News & Views |

    The design of an original molecular architecture featuring an unusual sterically congested C(sp2)–C(sp3) stereogenic axis with six high rotational barriers results in the formation of six stereoisomers. The configuration of this axis can be controlled by transition metal catalysis and one stereoisomer can be produced selectively.

    • Damien Bonne
    •  & Jean Rodriguez
    Nature Catalysis 4, 451-452
  • News & Views |

    All-carbon quaternary centres are challenging targets in organic synthesis. Now, the development of a zinc-catalysed desymmetrization method enables the synthesis of chiral alcohols with all-carbon quaternary centres by the selective reduction of symmetrical α,α-disubstituted malonates.

    • Jadwiga Gajewy
    •  & Marcin Kwit
    Nature Chemistry 13, 623-624